In This Section
Dr. Oliver investigates the mechanisms governing T cell activation and protective immunity. Her goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.
Dr. Oliver's research centers on identifying ubiquitin ligases and then using genetic, cellular, and biochemical approaches to define how those enzymes regulate immune cell function.
Some of her recent efforts have focused on catalytic ubiquitin ligases of the Nedd4-family. Along with colleagues in her lab, she identified a small family of membrane tethered adaptors, Ndfip1 and Ndfip2, that activate Nedd4-family ligases, and determined that these adaptors regulate T cell activation, CD4 differentiation and effector function, and Treg cell metabolism, and lineage stability. Dr. Oliver and her team combined this information on biologic function with biochemical data in which it defined precisely how these adaptors activate the enzymatic activity of Nedd4-family ligases. Dr. Oliver is now using this information in the rational design of therapeutics. Based on the data, such therapeutics will be particularly useful in the treatment of autoimmune and/or allergic disease.
In addition, Dr. Oliver's recent work has employed systems biology approaches in which it has integrated transcriptome, proteome, and ubiquitome information to identify Cullin E3 ubiquitin ligases that are particularly active as T cells transition from resting to activated states. She has now generated genetic models in which to test the biologic relevance of these ligases in protective immune responses, and she and her lab team are now poised to define how cullin ligases form distinct ubiquitin complexes in T cells or other immune cells, and the unique set of substrates targeted by these complexes. Answering these questions will position investigators to translate this information into new therapies for patients.
Education and Training
BS, North Carolina State University (Zoology), 1989
PhD, University of North Carolina at Chapel Hill (Pathology), 1998
Fellowship, National Jewish Health (Immunology), 2007
Titles and Academic Titles
Scientific Director for the Core Facilities at CHOP Research Institute
Co-Chief, Division of Protective Immunity
Co-Leader, Protective Immunity and Immunopathology Research Affinity Group
Associate Professor of Pathology and Laboratory Medicine
Abramson Cancer Center, 2008-
Institute for Immunology, University of Pennsylvania, 2010-
Leukemia and Lymphoma Society Fellow, 1999-2002
Christopher and Peter Gitzen Fellowship, 2000-2001
Howard Hughes Medical Institute, 2002-2005
Foerderer Award, 2008-2009
American Asthma Foundation Scholar, 2013-2016