Dr. Hill seeks to understand how the immune system contributes to the two most common chronic diseases of childhood: allergy and obesity. He uses clinical and epidemiological information to guide basic and translational research on the genetic, epigenetic, and immunologic basis of these important conditions.
Classic food allergies are mediated through immunoglobulin E and manifest as hives, vomiting, and anaphylaxis. Dr. Ruffner investigates the immune mechanisms of food allergy disorders which are not mediated through immunoglobulin E. In particular, the mechanisms of eosinophilic esophagitis and food-protein induced enterocolitis syndrome are of particular interest in Dr. Ruffner's laboratory.
Dr. Oliver investigates the mechanisms governing T cell activation and protective immunity. Her goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.
Dr. Zorc's work focuses on the intersection of interventional clinical research, quality improvement (QI), and clinical informatics. He has formal certification in epidemiology, QI methodology, and clinical informatics, and has participated in multi-center research networks, guideline and improvement collaboratives, and electronic health record development locally and nationally.
Dr. Shults works to develop statistical methods for longitudinal data that include semi-parametric approaches to account for subject/cluster level associations and maximum likelihood-based approaches for simulation and analysis of discrete longitudinal outcomes that may have overdispersion.
Dr. Tauber is an attending pulmonologist at Children's Hospital of Philadelpiha, and an associate professor of Clinical Pediatrics at the Perelman School of Medicine of the University of Pennsylvania. Her research focuses on asthma and sleep disordered breathing.
Dr. Jyonouchi, is an attending physician with the Division of Allergy and Immunology and the Center for Cornelia de Lange Syndrome and Related Diagnoses at Children's Hospital of Philadelphia. His research focuses on immunodeficiency in Cornelia de Lange syndrome and other genetic syndromes, and asthma.
Dr. Spergel focuses on translational research in IgE-mediated and non-IgE-mediated food allergy, examining novel clinical methods for desensitization and curing food allergy. His other main projects are to identify predictive factors for severity of reactions using molecular, physiologic, and clinical parameters.