Results for Ubiquitin Ligase

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Paula M. Oliver, PhD
Paula M. Oliver

Dr. Oliver investigates the mechanisms governing T cell activation and protective immunity. Her goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.

E-mail:
oliverp1 [at] chop.edu
Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] chop.edu
Craig H. Bassing, PhD
Craig H. Bassing

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:
bassing [at] chop.edu

Protein Network Signals Found to Drive Myeloid Leukemias

Published on
Jun 14, 2017
in Press Releases
CHOP Team’s Discovery May Advance Treatments

Putting the Brakes on Allergic Response

Published on
Apr 21, 2016
in Cornerstone Blog
When you have a chronic allergic disorder, it’s easy to blame the trigger — an early pollen season or furry pet — but the real culprit is your own immune system. Designed to attack foreign substances such as bacteria and viruses, T cells are the immune system’s watchdog to recognize serious threats. But sometimes T cells can be too zealous and set in motion a signaling cascade that can cause allergic reactions to everyday things and even attack your body’s healthy cells by mistake.

Study Aims to Reveal Novel Drivers of Allergic Disease

Published on
Sep 8, 2014
in Cornerstone Blog
Investigators at The Children’s Hospital of Philadelphia are studying the underlying biological features that could be common from one allergic disease to another.

Oliver Laboratory

Oliver Laboratory

The Oliver Lab focuses on revealing mechanisms governing T cell activation and protective immunity. Its goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.

Division of Protective Immunity

Protective Immunity

Leveraging innovative experimental methodology, computational approaches, and molecular tools to better understand immune system development, immune response to microorganisms, and mucosal immunology.

Bassing Laboratory

Bassing Lab

The goals of research in the Bassing Lab are to elucidate the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

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