Protective Immunity and Immunopathology Research Affinity Group



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Infectious diseases remain the leading cause of death for children around the world. Researchers at Children’s Hospital employ various approaches to better understand how protective immunity develops, as well as the reveal the causes and consequences of immunopathology. These approaches are helping to define how the immune system functions to eliminate infectious agents, how pathogens have evolved to evade the immune system, how to boost the immune response with vaccines, and how failures in immune function drive disease. Alternatively, sometimes the immune system becomes activated in the absence of pathogen encounter. This will initiate inflammatory diseases that are often treated by dampening the immune response, while still minimizing the risk of infection.

Because many diseases involve a component of immune system dysfunction, in 2015 Children’s Hospital established the Protective Immunity and Immunopathology Affinity Group. This dynamic and multidisciplinary group includes investigators from fields such as cancer immunotherapy, gene therapy, immunology, infectious disease, allergy, rheumatology and vaccine development.

The Protective Immunity and Immunopathology Affinity Group helps to build connections between investigators as they collaborate in their research endeavors and apply their shared knowledge towards a better understanding of the immune system and its powers to protect and heal.

In addition, as discoveries in the laboratory shed light on how the immune system regulates its own function, the Protective Immunity and Immunopathology Affinity Group helps investigators navigate the novel and exciting approaches that are being developed to treat these diseases.