Tong Laboratory Publications

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Below is a list of selected publications from the Tong Laboratory.

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia
The Journal Of Clinical Investigation · June, 2023
LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells
Blood Advances · February, 2022
Depalmitoylation rewires FLT3-ITD signaling and exacerbates leukemia progression
Blood · December, 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
Cell Stem Cell · July, 2021
The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination
Blood · April, 2019
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
Nat Commun · September, 2018
CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies
Genes & Development · May, 2017
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
The Journal Of Clinical Investigation · April, 2016
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells
Cell Stem Cell · January, 2016
MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling
Blood · March, 2015
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells
The Journal Of Clinical Investigation · June, 2012
Lnk constrains myeloproliferative diseases in mice
The Journal Of Clinical Investigation · June, 2010
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
The Journal Of Clinical Investigation · August, 2008
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
The New England Journal Of Medicine · February, 2007