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Results for Hematopoietic Stem Cells

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Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] chop.edu
Peter Kurre, MD
Peter Kurre

Dr. Kurre's laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve the understanding of the progressive hematopoietic failure in patients with bone marrow failure and FA, broaden diagnostic approaches, and develop next generation therapies.

E-mail:
kurrep [at] chop.edu
Timothy S. Olson, MD, PhD
Timothy S. Olson Headshot

Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.

E-mail:
olsont [at] chop.edu
Deborah L. French, PhD
Deborah French

Dr. French came to CHOP in 2008 to establish the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics. She is an internationally recognized researcher involved in multi-investigator teams that utilize pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.

E-mail:
frenchd [at] chop.edu
Stella T. Chou, MD
Stella T. Chou, MD

Dr. Chou focuses on regenerative blood cellular therapy, the mechanisms of normal human hematopoietic development, and the pathophysiology of pediatric hematologic diseases.

E-mail:
chous [at] chop.edu
Alan W. Flake, MD
Alan W. Flake

Dr. Flake is a general pediatric surgeon with a clinical and research focus on prenatal treatment ranging from the fetal surgical repair of anatomic anomalies to prenatal stem cell and gene therapy. He has extensive experience in developing rodent, canine, and sheep models for in utero transplantation and for investigating fetal surgery for anatomic malformations.

E-mail:
flake [at] chop.edu
Mortimer Poncz, MD
Mortimer Poncz

Dr. Poncz investigates the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes are the central foci of his laboratory work. Many of his studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

E-mail:
poncz [at] chop.edu
Stephan A. Grupp, MD, PhD
Stephan A. Grupp

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

E-mail:
grupp [at] chop.edu
Hannah-Lise Tirado Schofield, PhD, ABPP-CN
Hannah-Lise Tirado Schofield

Dr. Schofield's research focuses on neurocognitive outcomes of oncology treatment. Her areas of interest are acute and long-term neurotoxicities and cognitive sequelae of cellular therapy, including hematopoietic stem cell transplant and chimeric antigen receptor (CAR) T-cell therapy.

E-mail:
schofieldh [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
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In this section

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  • Principal Investigator / Faculty (10)
  • Researcher / Lab Personnel (8)

Organizations

  • Comprehensive Bone Marrow Failure Center (5)
  • Department of Pediatrics (3)
  • Division of Hematology (3)
  • Division of Oncology (2)
  • Kurre Laboratory (2)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (2)
  • Bernt Laboratory (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Childhood Cancer Research (1)
  • Chou Laboratory (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Division of Allergy and Immunology (1)
  • Human Pluripotent Stem Cell Core (1)
  • Immune Dysregulation Program (1)

In this section

Filter By

  • Principal Investigator / Faculty (10)
  • Researcher / Lab Personnel (8)

Organizations

  • Comprehensive Bone Marrow Failure Center (5)
  • Department of Pediatrics (3)
  • Division of Hematology (3)
  • Division of Oncology (2)
  • Kurre Laboratory (2)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (2)
  • Bernt Laboratory (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Childhood Cancer Research (1)
  • Chou Laboratory (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Division of Allergy and Immunology (1)
  • Human Pluripotent Stem Cell Core (1)
  • Immune Dysregulation Program (1)
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