Bioinformatics | CHOP Research Institute

Cornerstone Blog

What are the Origins and Implications of Intron Retention Quantitative Trait Loci in Human Tissues?

Published on

Nov 13, 2025

What are the Origins and Implications of irQTLs in Human Tissues?

The results of this study help identify the causes and consequences of molecular changes in RNA that arise from genetic differences among individuals.

Ko Laboratory for Advanced Physiologic Monitoring

The Ko laboratory develops innovative physiologic monitoring technologies and therapeutic approaches to improve detection and treatment of critical organ dysfunction in pediatric critical care patients with particular emphasis in cardiopulmonary failure, resuscitation, and brain injury.

Cornerstone Blog

Mapping Underpinnings of Autism, Schizophrenia with Genetic and Genomic Tools

Published on

Aug 19, 2024

Mapping the genetic underpinnings of autism, schizophrenia

In two new studies, the Gandal Lab has identified thousands of new gene transcripts.

Cornerstone Blog

Researchers Building Childhood Cancer Isoform Atlas to Find Immunotherapy Targets

Published on

Jan 29, 2024

Researchers Building Childhood Cancer Isoform Atlas

With funding from the National Cancer Institute’s Childhood Cancer Data Initiative, CHOP researchers are identifying new immunotherapy targets.

Mitochondria and Cancer Connections (MC²) Research Program

The Mitochondria and Cancer Connections (MC²) Research program leverages knowledge from existing centers to establish a novel, cutting-edge research initiative and enable the development of mechanistic understanding and novel therapeutic opportunities at the intersection of mitochondrial disease and pediatric cancer.

Tiffany Ko, PhD

Dr. Ko's research focus is the development of non-invasive diffuse optical tools to identify critical periods of neurological vulnerability and to facilitate individualized care pathways to mitigate subsequent neurological injury in critically-ill children.

E-mail:

kotiff [at] chop.edu

Cornerstone Blog

Featured Research Trainee: Allergy Bioinformatics With Megha Lal, PhD

Published on

Aug 3, 2023

Our August Featured Research Trainee is Megha Lal, PhD, who investigates the mechanism of less common forms of food allergies such as eosinophilic esophagitis.

Wang Laboratory

Research in the Wang Laboratory focuses on the development of bioinformatics methods to improve the understanding of the genetic basis of human diseases, and the integration of electronic health records and genomic information to facilitate genomic medicine on scale.

Stephen R. Master, MD, PhD

Dr. Master works to understand the biochemical pathways related to inborn errors of metabolism, particularly as they relate to mitochondrial function. He also focuses on bioinformatics and machine learning solutions to problems in mass spectrometry and laboratory medicine.

E-mail:

masters [at] chop.edu

Department of Biomedical and Health Informatics

The Department of Biomedical and Health Informatics (DBHi) explores how data, technology, and knowledge converge to improve scientific research and patient care.