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Tiffany Ko, PhD
Research Scientist
Dr. Ko's research focus is the development of non-invasive diffuse optical tools to identify critical periods of neurological vulnerability and to facilitate individualized care pathways to mitigate subsequent neurological injury in critically-ill children.
Bio
Dr. Ko is a Research Scientist in the Resuscitation Science Center (RSC) where she leads development and application of non-invasive, optical neuromonitoring technologies to detect and help mitigate neurological injury in preclinical and clinical studies of resuscitation and extracorporeal life support. She also leads implementation of preclinical data architecture and data standardization within the RSC to facilitate predictive model development with an emphasis on prediction of resuscitation success and of neurological injury.
Research focuses include:
- Diffuse optical techniques for non-invasive measurement of tissue oxygen saturation, blood volume, blood flow, oxygen metabolism and mitochondrial health.
- Examining the relationship of cerebral and systemic physiologic response to clinical interventions.
- Developing brain-directed management strategies to improve neurological outcomes following cardiopulmonary resuscitation and extracorporeal life support (e.g., cardiopulmonary bypass, ECMO).
- Preclinical large animal bioinformatics and machine learning for prediction of neurological injury.
Education and Training
BS, Princeton University (Electrical Engineering), 2009
MS, University of California Berkley (Bioengineering, Translational Medicine), 2012
PhD, University of Penn (Bioengineering), 2018
Titles and Academic Titles
Research Scientist
Professional Memberships
Society of Functional Near Infrared Spectroscopy, 2021-
American Heart Association, 2020-
Optica, 2018-
International Society for Cerebral Blood Flow and Metabolism, 2018-
Society of Photo-Optical Instrumentation Engineers, 2017-
American Society for Engineering Education, 2017-2018
Professional Awards
Emerging Innovators in Collaborative Science Award, CHOP, 2022
Young Investigator Award, American Heart Association Resuscitation Science Symposium, 2020
Publication Highlights
PubMed:
Ko TS, Catennacio E, Shin SS, Stern J, Massey SL, Kilbaugh TJ, Hwang M. Advanced Neuromonitoring Modalities on the Horizon: Detection and Management of Acute Brain Injury in Children. Neurocrit Care. 2023 Jun; 38(3): 791-811. PMID: 36949362
Wang L, Cochran JM, Ko T, Baker WB, Abramson K, He L, Busch DR, Kavuri V, Linn RL, Parry S, Yodh AG, Schwartz N. Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging. Nat Biomed Eng. 2022 Sep; 6(9): 1017-1030. PMID: 35970929
Ko TS, Mavroudis CD, Benson EJ, Forti RM, Melchior RW, et al. Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass. Metabolites. 2022 Aug; 12(8). PubMed PMID: 36005609
Hasan Ayaz H, Baker WB, et al. Optical imaging and spectroscopy for the study of the human brain: status report. Neurophotonics. 2022 Aug; 9(Suppl 2): S24001. PMID: 36052058
Ko TS, Mavroudis CD, Morgan RW, Baker WB, Marquez AM, Boorady TW, Devarajan M, Lin Y, Roberts AL, Landis WP, Mensah-Brown K, Nadkarni VM, Berg RA, Sutton RM, Yodh AG, Licht DJ, Guo W, Kilbaugh TJ. Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation. Sci Rep. 2021 Feb; 11(1):3828. PMID: 33589662
Active Grants/Contracts
Noninvasive Diagnosis of Intracranial Hypertension with a Backpack Optical Spectroscopy System
Department of Defense
2022
Co-I
Biomedical Optical Devices to Monitor Cerebral Health
CHOP Frontier Program
2019
Co-I
Novel Technology and Discovery Development for Traumatic Brain Injury
Toyota Way Forward Fund
2023
Co-I