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Dr. Ko's research focus is the development of non-invasive diffuse optical tools to identify critical periods of neurological vulnerability and to facilitate individualized care pathways to mitigate subsequent neurological injury in critically-ill children.
Dr. Ko is a Research Scientist in the Resuscitation Science Center (RSC) where she leads development and application of non-invasive, optical neuromonitoring technologies to detect and help mitigate neurological injury in preclinical and clinical studies of resuscitation and extracorporeal life support. She also leads implementation of preclinical data architecture and data standardization within the RSC to facilitate predictive model development with an emphasis on prediction of resuscitation success and of neurological injury.
Research focuses include:
- Diffuse optical techniques for non-invasive measurement of tissue oxygen saturation, blood volume, blood flow, oxygen metabolism and mitochondrial health.
- Examining the relationship of cerebral and systemic physiologic response to clinical interventions.
- Developing brain-directed management strategies to improve neurological outcomes following cardiopulmonary resuscitation and extracorporeal life support (e.g., cardiopulmonary bypass, ECMO).
- Preclinical large animal bioinformatics and machine learning for prediction of neurological injury.
Education and Training
BS, Princeton University (Electrical Engineering), 2009
MS, University of California Berkley (Bioengineering, Translational Medicine), 2012
PhD, University of Penn (Bioengineering), 2018
Titles and Academic Titles
Society of Functional Near Infrared Spectroscopy, 2021-
American Heart Association, 2020-
International Society for Cerebral Blood Flow and Metabolism, 2018-
Society of Photo-Optical Instrumentation Engineers, 2017-
American Society for Engineering Education, 2017-2018
Emerging Innovators in Collaborative Science Award, CHOP, 2022
Young Investigator Award, American Heart Association Resuscitation Science Symposium, 2020
Noninvasive Diagnosis of Intracranial Hypertension with a Backpack Optical Spectroscopy System
Department of Defense
Biomedical Optical Devices to Monitor Cerebral Health
CHOP Frontier Program
Novel Technology and Discovery Development for Traumatic Brain Injury
Toyota Way Forward Fund