The departments at Children's Hospital of Philadelphia are closely tied to the Research Institute, many with significant research components. Their laboratory efforts led by Principal Investigators result in the state-of-the-art medical care.

Division of Adolescent Medicine

The mission of the Division of Adolescent Medicine at CHOP is to improve the health and well-being of adolescents and young adults regionally, nationally, and globally. Research is an important part of this mission. Our research program aims to generate new knowledge in collaboration with trainees through clinical research, population-based research, translational research, community-based participatory research, clinical quality improvement initiatives, and medical education research. We are also committed to participating in activities designed to facilitate the translation of science and the best available research into practice, programs, and policy.
Detailed information regarding the Division of Adolescent Medicine's research program can be found on the Division's research website.

Division of Allergy and Immunology

The Division of Allergy and Immunology is a pioneer in performing cutting edge basic science, translational, and clinical research pertaining to the contribution of the immune system to pediatric disease. Research in the Division focuses on primary immunodeficiency, allergy, and auto-immunity. Our faculty and fellows have intimate connections to the University of Pennsylvania Institute for Immunology and contribute to animal and translational-based research programs aimed at bettering our mechanistic understanding of inflammatory disease states. Additionally, we have an active clinical research program which participates in multi-center trials related to food allergy and other allergic conditions. More information can be found at the website.

Department of Biomedical and Healthcare Informatics (DBHi)

The Department of Biomedical and Healthcare Informatics (DBHi) provides an academic home for all research informatics activities at The Children’s Hospital of Philadelphia, including the development and deployment of intellectual, technical, and educational resources in biomedical computing. DBHi encompasses units for bioinformatics, scientific computing, and clinical data reporting from hospital systems; partners with existing CHOP-based groups for outcomes research, quality improvement, decision support, biostatistics, and bioethics; and closely coordinates the analysis of high-throughput genomic data derived from CHOP-based samples. DBHi also consists of a translational informatics group that develops novel technical solutions for research CHOP-wide. DBHi serves as the primary informatics interface with the University of Pennsylvania through a joint CTSA award and through its collaborative relationship with the University’s Institute for Biomedical Informatics(IBI). DBHi is a funded partner in over five extramurally-resourced NIH consortia, including the Intellectual and Developmental Disability Research Center (IDDRC) programs, the NHGRI Clinical Sequencing and Exploratory Research (CSER) consortium, the NCATS Clinical and Translational Science Award program, and the National Pediatric Learning Health System (PEDSnet). DBHi faculty and staff have worked extensively on a variety of federally sponsored and internal projects, including development of EHR-embedded clinical decision support applications, patient portal systems, and general clinical data reporting. More information can be found at the website.

Department of Child and Adolescent Psychiatry and Behavioral Sciences

The Department of Child and Adolescent Psychiatry and Behavioral Sciences includes a wide range of research activities, such as the use of transgenic mice and mice and human stem cells to model human brain development in normal and disease-like conditions, the study of genetics of neuropsychiatric disorders, and the development of new approaches for optimizing the education of children with ADD in public schools. The ultimate goal of this research, whether focused on genes, brain circuitry, psychosocial influences on behavior, or on combinations of these, the is to improve both the immediate health and the developmental trajectory of children in our care.

Division of Neonatology

The ongoing research programs in the Division of Neonatology encompass basic science, clinical studies, and health services/health policy research. The common goal of these efforts is to improve our understanding of the causes and optimal therapies for diseases affecting newborns. Investigators involved in these studies have expertise in clinical trials, neonatal lung disease, neonatal immunology, cardiovascular development, proteomics, nitric oxide biology, neurodevelopment and fetal origins of adult diseases such as diabetes and obesity.
Detailed information regarding the Division of Neonatology research resources can be found on the Division's research website.