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Yi Xing, PhD
Yi Xing
Director of the Center for Computational and Genomic Medicine

Dr. Xing is the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.

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Bio

Dr. Xing’s research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology. He is the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. Prior to his appointment at CHOP and Penn, Dr. Xing was a professor of Microbiology, Immunology, and Molecular Genetics at University of California Los Angeles, and served as program director of UCLA’s Bioinformatics Interdepartmental PhD Program. Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.

Education and Training

PhD, University of California Los Angeles, (Molecular Biology, Bioinformatics), 2006

Titles and Academic Titles

Director of the Center for Computational and Genomic Medicine

Francis West Lewis Endowed Chair in Computational and Genomic Medicine

Professor of Pathology and Laboratory Medicine at the University of Pennsylvania

Publication Highlights

Pubmed:
Xin R, Gao Y, Gao Y, Wang R, Kadash-Edmondson KE, Liu B, Wang Y, Lin L, Xing Y. isoCirc catalogs full-length circular RNA isoforms in human transcriptomes. Nat Commun. 2021 Jan; 12(1): 266. PubMed PMID 33436621
Demirdjian L, Xu Y, Bahrami-Samani E, Pan Y, Stein S, Xie Z, Park E, Wu YN, Xing Y. Detecting Allele-Specific Alternative Splicing From Population-Scale RNA-Seq Data. Am J Hum Genet. 2020 Sep; 107(3): 461-472. PubMed PMID 32781045
Zhang Y, Yang HT, Kadash-Edmondson K, Pan Y, Pan Z, Davidson BL, Xing Y. Regional Variation of Splicing QTLs in Human Brain. Am J Hum Genet. 2020 Aug; 107(2): 196-210. PubMed PMID 32589925
Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON, Xing Y. (2020) Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proc Nat Acad Sci USA. 2020 Mar; 117(10): 5269-5279. PubMed PMID: 32086391
Zhang Z, Pan Z, Ying Y, Xie Z, Adhikari S, Phillips J, Carstens RP, Black DL, Wu Y, Xing Y. Deep-learning augmented RNA-seq analysis of transcript splicing. Nat Methods. 2019 Apr; 16(4): 307-310. PubMed PMID 30923373