Philadelphia International Maternal Pediatric Adolescent AIDS Clinical Trials

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Children’s Hospital of Philadelphia is one of several clinical research sites in Philadelphia for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network. IMPAACT is a global collaboration of investigators, institutions, community representatives, and other partners organized for the purpose of significantly decreasing incident HIV and HIV-associated infections and decreasing mortality and morbidity due to HIV and HIV-associated infections and co-morbidities among infants, children, adolescents, and pregnant/postpartum women.

The Douglas laboratory at CHOP is the central immunology laboratory for the IMPAACT Network, and a specialty immunology laboratory.

Research Project Highlights:

  • Molecular and cellular immunologic studies of substance P in monocyte-macrophages
  • Discovery of the truncated form of NK1-R and demonstrated that SP antagonists block HIV through CCR5 and applied as novel HIV therapy
  • Research in cellular immunology and its relationship to the immunopathogenesis of HIV
  • Cellular and humoral immunologic studies, including studies of AIDS infection and of primary immunodeficiencies
  • Psychosocial and psychiatric interactions with the immune and nervous systems studies
  • Ongoing studies have demonstrated associations between substance P, impaired natural killer cell activity, and depression in HIV-infected individuals.