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Michelle Denburg, MD, MSCE
Michelle Denburg
Associate Professor of Pediatrics and Epidemiology

Dr. Denburg addresses fundamental limitations in understanding of skeletal morbidity in patients with chronic kidney disease, glomerular disease, and urinary stone disease, and develops resources to conduct observational research and trials to optimize health outcomes in these high risk populations.

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Bio

Michelle Denburg, MD, MSCE, is board certified in pediatric nephrology and is director of Research for the Division of Nephrology at CHOP. She is an associate professor of Pediatrics and Epidemiology and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania Perelman School of Medicine. She is a faculty member of the Clinical Futures, a CHOP Research Institute Center of Emphasis. She is an Attending Physician in the Cancer Survivorship Program and the CHOP-Penn Glomerular Clinic.

Dr. Denburg leads a multidisciplinary research program focused on complications of childhood kidney diseases, including chronic kidney disease (CKD), glomerular disease, and kidney stone disease, with a particular interest in bone health and altered mineral metabolism. Her research includes analyses of large electronic health record databases, and observational, translational, and interventional patient-oriented studies.

Dr. Denburg is the co-director of the Penn-CHOP Kidney Innovation Center. She is the associate director for the Pediatric Center of Excellence in Nephrology supported by funding from the National Institute of Diabetes and Digestive and Kidney Disease. She also served as co-PI in the NIDDK CKD Biomarkers Consortium to identify novel biomarkers for CKD progression in children. She initiated and leads GLEAN (Glomerular Learning Network), a multi-institutional collaborative focused on outcomes improvement in children with glomerular disease and is co-PI of the PRESERVE study (Preserving Kidney Function in Children with Chronic Kidney Disease) that is leveraging the health data resources of 16 centers to address evidence gaps in blood pressure management for children with CKD.

Dr. Denburg is committed to mentoring trainees and junior investigators engaged in clinical research. Mentees have included clinical fellows and junior faculty members in multiple subspecialties, medical students, residents, and biostatistics graduate students.

Education and Training

BS, Yale University, 1998

MD, Cornell University, 2003

Doris Duke Clinical Research Fellowship, 2001

Residency, New York-Presbyterian Morgan Stanley Children’s Hospital (Pediatrics), 2003-2006

Pediatric Fellowship, Children's Hospital of Philadelphia (Pediatric Nephrology), 2007-2010

Masters of Science in Clinical Epidemiology, University of Pennsylvania, 2010

Titles and Academic Titles

Associate Professor of Pediatrics and Epidemiology

Distinguished Endowed Chair in the Department of Pediatrics

Co-director Penn-CHOP Kidney Innovation Center

Associate Director Pediatric Center of Excellence in Nephrology

Director of Research, Division of Nephrology

Attending Physician

Professional Memberships

American Society of Pediatric Nephrology

International Pediatric Nephrology Association

American Society of Nephrology

Pediatric Nephrology Research Consortium

Professional Awards

American Society for Clinical Investigation (ASCI) Young Physician-Scientist Award, 2016

Member, Society for Pediatric Research, 2016

Pediatrics Residency Early Career Faculty Honor Roll, 2018

Pediatrics Residency Early Career Faculty Honor Roll, 2019

Excellence in Teaching Epidemiology Award, Center for Clinical Epidemiology and Biostatistics, 2020

Carole Marcus Mid-Career Award to Promote Career Development and Mentoring in Pediatric Research, 2020

American Society of Nephrology Distinguished Mentor Award, 2021

Member, American Society for Clinical Investigation (ASCI), 2022

Active Grants/Contracts

Evaluation of the Gut-Kidney Axis in Kidney Stone Disease
NIH
R01 DK122156
PI: Tasian GE, Denburg MR (Multiple PI)
07/01/2019 - 04/30/2023

The Impact of Glomerular Disorders on Bone Quality and Strength
NIH
R01 DK119266
PI: Nickolas T, Denburg MR (Multiple PI)
09/01/2018 - 08/31/2023

Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)
PCORI
PI: Forrest C, Denburg, MR (Multiple PI)
07/01/2021 - 06/30/2025

CHOP Pediatric Center of Excellence in Nephrology
NIH
P50 DK114786
PI: Furth SL
09/18/2017 - 08/31/2022

Skeletal Outcomes in Children and Young Adults with Glomerular Disease
NIH
R21 DK116151
PI: Denburg MR
09/03/2018 - 08/31/2022

Phosphate Binder Therapy and Chronic Kidney Disease in Children
NIH
U01 DK122013
PI: Salusky I, Role: Site PI
05/01/2020 - 04/30/2025