Atopic Dermatitis | CHOP Research Institute

FLG Mutations and Atopic Dermatitis

The primary objective is to confirm the association of the Filament-Aggregating Protein loss-of-function mutations with respect to the severity of disease and its association with components of the atopic triad within our Atopic Dermatitis cohort.

Food Allergy Center

Conducting laboratory, translational, and clinical research to revolutionize medications and therapies aimed at eradicating childhood food allergies.

Joy Wan, MD, MSCE

Dr. Wan focuses her research on chronic inflammatory skin diseases, primarily atopic dermatitis and psoriasis. Through her work she aims to understand and address the health, social, and life impacts of chronic skin disease in children.

E-mail:

wanj1 [at] chop.edu

Jennifer R. Heimall, MD

E-mail:

heimallj [at] chop.edu

Melanie A. Ruffner, MD, PhD

Classic food allergies are mediated through immunoglobulin E and manifest as hives, vomiting, and anaphylaxis. Dr. Ruffner investigates the immune mechanisms of food allergy disorders which are not mediated through immunoglobulin E. In particular, the mechanisms of eosinophilic esophagitis and food-protein induced enterocolitis syndrome are of particular interest in Dr. Ruffner's laboratory.

E-mail:

ruffner [at] chop.edu

Jonathan M. Spergel, MD, PhD

Dr. Spergel focuses on translational research in IgE-mediated and non-IgE-mediated food allergy, examining novel clinical methods for desensitization and curing food allergy. His other main projects are to identify predictive factors for severity of reactions using molecular, physiologic, and clinical parameters.

E-mail:

spergel [at] chop.edu

Cornerstone Blog

Getting in Step: Scientists Suggest Eosinophilic Esophagitis Part of Allergic March

Published on

Jun 25, 2018

Findings from new study support more active screening of allergic children for eosinophilic esophagitis symptoms.

Cornerstone Blog

Blood Test Screening for Food Allergy Has Limited Use in Infant Eczema

Published on

Dec 15, 2015

Researchers at The Children’s Hospital of Philadelphia wanted to determine how common it is for clinicians to actually see food allergies occur in patients with eczema by performing a blood test during infancy.