In This Section

Neil D. Romberg, MD
Neil D. Romberg

Dr. Romberg investigates the regulatory mechanisms enabling our immune systems to fight infections without injuring ourselves. He is particularly interested in the immune system of patients with primary immunodeficiency who are susceptible to both life-threatening infections and autoimmune diseases. Greater insights into these rare diseases may enable rationale development of targeted therapies for more common diseases with an immunologic basis.



Dr. Romberg investigates the regulatory mechanisms that enable our immune systems to vigorously attack infectious pathogens but not our own bodies. Particular topics of interest in Dr. Romberg's lab include the role of T regulatory cells in B cell tolerance, T follicular helper cell dysfunction in common variable immune deficiency-related autoimmune disease, and the role of novel genes and pathways in immunity.

Of particular interest to Dr. Romberg is the immune system of patients with primary immunological diseases (PID) who are susceptible to both life-threatening infections and to the development of autoimmune diseases. Greater insights into the pathology of these rare diseases will enable the rationale development of targeted therapies for PIDs and for more common diseases that have an immunologic basis.

In addition to basic scientific work, Dr. Romberg has discovered or has contributed to the discovery of several inherited diseases of the immune system and identified personalized therapies for affected patients. Such disorders include:

  • CD40LG duplication associated autoimmune disease (40DAD)
  • Combined CD28/CTLA4 haploinsufficiency
  • Autoinflammation with infantile enterocolitis (AIFEC)
  • Hypomorphic CARD11 mutation related atopic disease


Education and Training

BS, University of Michigan (Botany), 1999

MD, Pennsylvania State College of Medicine, 2004

Fellowship, Yale University School of Medicine (Allergy and Clinical Immunology), 2011

Titles and Academic Titles


Jeffrey Modell Endowed Chair in Pediatric Immunology Research

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

American Academy of Allergy, Asthma and Immunology, 2008-

Clinical Immunology Society, 2009-

University of Pennsylvania Institute for Immunology, 2015-

Professional Awards

Clinical Immunology Society/Talecris Primary Immune Deficiency Fellowship Award, 2011

Scholar of the NIH Child Health Research Center, 2012-2014

Timber Spears Endowment for Immunodeficiency Research Award Recipient, 2014-2015

Yale Center for Clinical Investigation Scholar Award, 2014-2015

American Society of Clinical Investigation Young Physician-Scientist Award, 2015

Publication Highlights

Cai Y, Abdel-Mohsen M, Tomescu C, Xue F, Wu G, Howell BJ, Ai Y, Sun J, Azzoni L, Le Coz C, Romberg N, Montaner LJ. BCL6 Inhibitor-mediated Downregulation of pSAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation. J Virol. 2018 Oct; pii: JVI.01073-18. doi: 10.1128/JVI.01073-18. [Epub ahead of print]
Le Coz C, Nolan BE, Trofa M, Kamsheh AM, Khokha MK, Lakhani SA, Novelli A, Zackai EH, Sullivan KE, Briuglia S, Bhatti TR, Romberg N. Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation. Front Immunol. 2018 Jul; 9:1715. doi: 10.3389/fimmu.2018.01715. eCollection 2018.
Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, LuQing Xu M, Lambert M, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. CVID patients with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2018 Jun; pii: S0091-6749(18)30897-2. doi: 10.1016/j.jaci.2018.06.012. [Epub ahead of print]
Le Coz C, Trofa M, Syrett CM, Martin A, Jyonouchi H, Jyonouchi S, Anguera MC, Romberg N. CD40LG duplication-associated autoimmune disease is silenced by non-random X-chromosome inactivation. J Allergy Clin Immunol. 2018 Jun; 141(6):2308-2311.e7. doi: 10.1016/j.jaci.2018.02.010. Epub 2018 Mar 2
Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat. Genet. 2014 Oct; 46(10):1135-1139. doi: 10.1038/ng.3066. Epub 2014 Sep 14