Dr. Romberg investigates the regulatory mechanisms that enable our immune systems to vigorously attack infectious pathogens but not our own bodies. Particular topics of interest in Dr. Romberg's lab include the role of T regulatory cells in B cell tolerance, T follicular helper cell dysfunction in common variable immune deficiency-related autoimmune disease, and the role of novel genes and pathways in immunity.

Of particular interest to Dr. Romberg is the immune system of patients with primary immunological diseases (PID) who are susceptible to both life-threatening infections and to the development of autoimmune diseases. Greater insights into the pathology of these rare diseases will enable the rationale development of targeted therapies for PIDs and for more common diseases that have an immunologic basis.

In addition to basic scientific work, Dr. Romberg has discovered or has contributed to the discovery of several inherited diseases of the immune system and identified personalized therapies for affected patients. Such disorders include:

• PU.1-mutated agammaglobulinemia (PU.MA)
• CD40LG duplication associated autoimmune disease (40DAD)
• Autoinflammation with infantile enterocolitis (AIFEC)

BS, University of Michigan (Botany), 1999

MD, Pennsylvania State College of Medicine, 2004

Fellowship, Yale University School of Medicine (Allergy and Clinical Immunology), 2011

Pediatric Residency and Chief Residency, New York University School of Medicine, 2008

Investigator

Jeffrey Modell Endowed Chair in Pediatric Immunology Research

Attending Physician

Assistant Professor of Pediatrics

American Academy of Allergy, Asthma and Immunology, 2008-

Clinical Immunology Society, 2009-

University of Pennsylvania Institute for Immunology, 2015-

Clinical Immunology Society/Talecris Primary Immune Deficiency Fellowship Award, 2011

Scholar of the NIH Child Health Research Center, 2012-2014

Timber Spears Endowment for Immunodeficiency Research Award Recipient, 2014-2015

Yale Center for Clinical Investigation Scholar Award, 2014-2015

Lady Barbara Colyton Prize for Autoimmune Research, 2021