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Contact
E-mail
tasiang [at] email.chop.edu
Location - People View
Room 11243

2716 South Street
Philadelphia, PA 19146
United States

Research Topics
Gregory Tasian, MD, MSCE
Gregory Tasian
Attending Urologist

Dr. Tasian and his research team use an epidemiologic framework, including randomized trials and multi-institutional observational studies, to examine the etiology of kidney stone disease and the comparative effectiveness of surgical interventions. He also employs machine learning of complex data to improve diagnosis, risk stratification, and prediction of treatment response for children and adults with benign urologic disease.

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Bio

The long-term goal of Dr. Tasian's clinical and research programs is to improve the lives of children with nephrolithiasis and congenital urologic disease. His research group uses a combination of large data analytics, behavioral economics, nutritional profiling, and human biospecimen analysis to discover determinants of kidney stone disease with the goal of translating this knowledge into new treatments for kidney stone prevention.

Active projects include examination of metabolic pathways in the gut-kidney axis that could be targets for novel therapeutics to prevent kidney stones. Specifically, Dr. Tasian is investigating the impact of diet and antibiotic exposure on the gut microbiome and metabolites in the intestinal and urinary tract and their contribution to calcium kidney stones in children and adults. He is also performing prospective cohort studies to compare stone clearance and patients’ experiences after alternative surgical interventions for kidney stones. He also applies machine learning to improve understanding of the pathophysiology, diagnosis, risk stratification, and prediction of treatment responses of benign urological disease among children.

Dr. Tasian and his team have made the following discoveries:

  • Characterized the rapid increase in kidney stone disease among children, adolescents, and young adult women.
  • Defined the precise relationship between daily temperatures and kidney stone presentation, which has important implications for the impact of climate change on human health.
  • Recently published the first evidence that oral antibiotics are associated with an increased risk of kidney stones. The risk was greatest for those exposed at younger ages, which could help explain the rapid increase in the incidence of nephrolithiasis among children.
  • Found that lower renal parenchymal area was associated with an increased risk of end-stage renal disease in boys with posterior urethral valves. Collaborations with Yong Fan at the University of Pennsylvania determined that machine learning of ultrasound images accurately identified children with congenital urologic disease.

Education and Training

BA, Trinity University (Biology and English), 2000

MSc, University of Oxford (Neuroscience), 2004

MD, Baylor College of Medicine, 2005

Fellowship, Children's Hospital of Philadelphia, 2013

MSCE, University of Pennsylvania (Clinical Epidemiology), 2014

Titles and Academic Titles

Attending Urologist

Assistant Professor of Urology in Surgery

Assistant Professor of Epidemiology in Biostatistics and Epidemiology

Professional Memberships

American Urological Association, 2007-

Society of Pediatric Urology, 2011-

Pediatric National Surgery Quality Improvement Program, 2014-

American College of Surgeons, 2014-

American Medical Association, 2014-

Society of University Urologists, 2014-

 

Professional Awards

Outstanding Patient Oriented Research Presentation; 22nd annual CHOP Research Poster Day, 2012, 2014

CPCE Pilot Grant Award, 2013

Best Poster Award; International Pediatric Nephrology Association, 2013

American Society for Clinical Investigation Young Physician-Scientist Award, 2016

Election to Research on Calculous Kinetics (ROCK) Society, 2017

Third place, American Urological Association Young Investigator Award, 2017

Publication Highlights

Tasian GE, Ross M, Song L, Audrain-McGovern J, Wiebe D, Warner SG, Henderson B, Patel A, Furth SL. Ecological Momentary Assessment of Factors Associated with Water Intake among Adolescents with Kidney Stone Disease. J Urol. 2019 Mar; 201(3):606-614. PMID: 30076905
Tasian GE, Jemielita T, Goldfarb DS, Copelovitch L, Gerber J, Wu Q, Denburg MR. Oral Antibiotic Exposure and Kidney Stone Disease. J Am Soc Nephrol. 2018 Jun; 29(6):1731-1740. PMCID: PMC6054354
Tasian GE, Ross ME, Song L, Sas DJ, Keren R, Denburg MR, Chu DI, Copelovitch L, Saigal CS, Furth SL. Annual Incidence of Nephrolithiasis among Children and Adults in South Carolina from 1997 to 2012. Clin J Am Soc Nephrol. 2016 Mar; 11(3):488-96. PMCID: PMC4791823
Tasian GE, Pulido JE, Gasparrini A, Saigal CS, Horton BP, Landis JR, Madison R, Keren R. Daily mean temperature and clinical kidney stone presentation in five U.S. metropolitan areas: a time-series analysis. Environ Health Perspect. 2014 Oct; 122(10):1081-7. PMID: 25009122
Pulido JE, Furth SL, Zderic SA, Canning DA, Tasian GE. Renal parenchymal area and risk of ESRD in boys with posterior urethral valves. Clin J Am Soc Nephrol. 2014 Mar; 9(3):499-505. PMCID: PMC3944775

Links of Interest