The long-term goal of Dr. Tasian's clinical and research programs is to improve the lives of children with nephrolithiasis and congenital urologic disease. He founded the PKIDS Care Improvement Network, a community of patients, caregivers, and clinicians who generate and apply knowledge that improves outcomes for children with kidney stones at 30 US healthcare systems. He also co-directs USDHub, a research resource that will aggregate data from seven health systems that participate in PEDSnet and STAR, two PCORnet clinical research networks, into one comprehensive platform drawing data from a cohort of more than 230,000 patients suffering from kidney stone disease.

His research group uses a combination of large data analytics, behavioral economics, nutritional profiling, and human biospecimen analysis to discover determinants of kidney stone disease with the goal of translating this knowledge into new treatments for kidney stone prevention.

Active projects include examination of metabolic pathways in the gut-kidney axis that could be targets for novel therapeutics to prevent kidney stones. Specifically, Dr. Tasian is investigating the impact of diet and antibiotic exposure on the gut microbiome and metabolites in the intestinal and urinary tract and their contribution to calcium kidney stones in children and adults. He is also performing prospective cohort studies to compare stone clearance and patients' experiences after alternative surgical interventions for kidney stones. He also applies machine learning to improve understanding of the pathophysiology, diagnosis, risk stratification, and prediction of treatment responses of benign urological disease among children.

Dr. Tasian and his team have made the following discoveries:

• Characterized the rapid increase in kidney stone disease among children, adolescents, and young adult women.
• Defined the precise relationship between daily temperatures and kidney stone presentation, which has important implications for the impact of climate change on human health.
• Recently published the first evidence that oral antibiotics are associated with an increased risk of kidney stones. The risk was greatest for those exposed at younger ages, which could help explain the rapid increase in the incidence of nephrolithiasis among children.
• Found that lower renal parenchymal area was associated with an increased risk of end-stage renal disease in boys with posterior urethral valves. Collaborations with Yong Fan at the University of Pennsylvania determined that machine learning of ultrasound images accurately identified children with congenital urologic disease.

BA, Trinity University (Biology and English), 2000

MSc, University of Oxford (Neuroscience), 2004

MD, Baylor College of Medicine, 2005

Fellowship, Children's Hospital of Philadelphia (Pediatric Urology), 2013

MSCE, University of Pennsylvania (Clinical Epidemiology), 2014

Attending Urologist

Associate Professor of Surgery and Epidemiology (with tenure)

Director, Pediatric KIDney Stone (PKIDS) Care Improvement Network

Surgical Director, Kidney Stone Center

Endowed Chair, Cheers for CHOP Endowed Chair in the Clinical Epidemiology of Pediatric Urologic Disease

Director, Center for Outcomes REsearch in Surgery (CORES)

Associate Director for Clinical Trials, CHOP Clinical Futures

Associate Professor of Urology in Surgery, Perelman School of Medicine at the University of Pennsylvania

Associate Professor of Epidemiology in Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania

Core Faculty, CHOP PolicyLab

Core Faculty, Clinical Futures

American Urological Association, 2007-

Society of Pediatric Urology, 2011-

American College of Surgeons, 2014-

American Medical Association, 2014-

Society of University Urologists, 2014-

Urology Care Foundation Patient Education (Pediatric Health Committee), 2017-

American Urological Association National Urology Research Agenda (NURA) (Committee Member, Nephrolithiasis Section), 2017-

Rare Kidney Stone Consortium (External Advisory Council), 2018-2019

Hyperoxaluria Foundation (Scientific Advisory Board), 2018-

Oxalosis & Hyperoxaluria Foundation (Scientific Advisory Committee), 2018

Urologic Diseases in America Compendium Project, National Institutes of Health (Technical Review Panel), 2019-

NIH/NIDDK Urologic and Urogynecologic Applications Special Emphasis Panel (Study Section), 2019-

Director, Pediatric KIDney Stone (PKIDS) Care Improvement Network, 2019-

Outstanding Patient Oriented Research Presentation; 22nd annual CHOP Research Poster Day, 2012, 2014

CPCE Pilot Grant Award, 2013

Best Poster Award; International Pediatric Nephrology Association, 2013

American Society for Clinical Investigation Young Physician-Scientist Award, 2016

Election to Research on Calculous Kinetics (ROCK) Society, 2017

Third place, American Urological Association Young Investigator Award, 2017

Basic Science Prize, Societies for Pediatric Urology (SPU). American Urological Association Annual Meeting, Chicago, IL, 2019

Philadelphia Magazine's Top Doctors in Pediatric Urology, 2022

Main Line Today Top Docs, Urology, 2022

Presidential Leadership Award, Societies for Pediatric Urology, 2023

Active

Evaluation of the Gut-Kidney Axis in Kidney Stone Disease

• National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
• 2024-2029
• PI: Gregory E. Tasian, MD, MSc, MSCE

The Philadelphia Program for Mentored Research Training in Kidney Urologic, and Hematologic Diseases

• National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
• 2024-2028
• Co-PI: Gregory E. Tasian, MD, MSc, MSCE

Urinary Stone Disease Hub (USDHub)

• National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
• 2024-2029
• PI: Gregory E. Tasian, MD, MSc, MSCE

Personalizing Outcomes in Pediatric Nephrolithiasis

• National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
• 2024-2027
• PI: Gregory E. Tasian, MD, MSc, MSCE

CHOP Kidney Stone Center Frontier Program

• Children's Hospital of Philadelphia (CHOP)
• 2024-2027
• PI: Gregory E. Tasian, MD, MSc, MSCE

Harnessing Behavior to Decrease Urinary Stone Disease Morbidity

• National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
• 2016-2026
• PI: Gregory E. Tasian, MD, MSc, MSCE

Clinical Futures Profile

Antibiotics May Raise the Risk for Kidney Stone (New York Times, May 10, 2018)

CHOP study links antibiotic use with risk of kidney stones (Philadelphia Inquirer, May 10, 2018).

CHOP researchers: Why are so many kids getting kidney stones? (WHYY, May 8, 2018)

Climate change may increase kidney stone risk (news@JAMA, July 10, 2014)

Climate change may bring more kidney stones (Science Daily, July 10, 2014)

Pediatric KIDney Stone (PKIDS) Care Improvement Network (PKIDS)

PKIDS