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Andrei Thomas-Tikhonenko, PhD
Chief, Division of Cancer Pathobiology
Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.
Bio
Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.
He is a tenured professor of Pathology and Laboratory Medicine, receiving continuous funding for his research for nearly two decades. His robust external funding support, from federal sources as well as private foundations, has allowed Dr. Thomas-Tikhonenko to maintain an active lab that is currently composed of several fellows, two bioinformatics scientists, three thesis-level graduate students, and one technician.
Dr. Thomas-Tikhonenko's lab is an integral part of the Center for Childhood Cancer Research, presenting opportunities to foster new collaborations with key physician-scientists and pursue several translational projects. Because of his prior contributions to the field of immunobiology, in 2013 he became investigator of the multi-institutional Stand Up to Cancer-St. Baldrick's Pediatric Cancer Dream Team.
Education and Training
BS, Moscow State University (Biochemistry/Virology), 1984
PhD, Russian Academy of Medical Sciences (Oncology/Virology), 1988
Fellowship, Fred Hutchinson Cancer Research Center (Retrovirology), 1992
Titles and Academic Titles
Chief, Division of Cancer Pathobiology
Mildred L. Roeckle Endowed Chair at Children's Hospital of Philadelphia
Professor of Pathology and Laboratory Medicine
Professional Memberships
American Association for Cancer Research, 1999-
International Cancer Microenvironment Society, 2007-
American Society of Hematology, 2008-
Alex's Lemonade Stand Foundation, 2009-
Professional Awards
Special Fellow, Leukemia Society of America, 1994
Elizabeth and William Whitney Clark Developmental Chair in Oncology, University of Pennsylvania, 1999
Pfizer Award for Research Excellence, Pfizer Animal Health, 2005
4th Annual Award for Excellence in Teaching in Cancer Biology, University of Pennsylvania, 2012
Ethel Brown Foerderer Fund for Excellence Award, The Children's Hospital of Philadelphia, 2013
Immunogenomics Pediatric Dream Team Investigator, SU2C - St. Baldrick's Foundation, 2013
Publication Highlights
PubMed:
Asnani M, Thomas-Tikhonenko A. Exons of Leukemia Suppressor Genes: Creative Assembly Required. Trends Cancer. 2018 Dec; 4(12):796-798. PMID: 30470300
Black KL, Naqvi AS, Asnani M, Hayer KE, Yang SY, Gillespie E, Bagashev A, Pillai V, Tasian SK, Gazzara MR, Carroll M, Taylor D, Lynch KW, Barash Y, Thomas-Tikhonenko A. Aberrant splicing in B-cell acute lymphoblastic leukemia. Nucleic Acids Res. 2018 Nov; 46(21):11357-11369. PMID: 30357359
Bagashev A, Sotillo E, Tang CA, Black KL, Perazzelli J, Seeholzer SH, Argon Y, Barrett DM, Grupp SA, Hu CA, Thomas-Tikhonenko A. CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum. Mol Cell Biol. 2018 Aug; PMID: 30104252
Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A. Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer Discov. 2015 Dec; 5(12):1282-95. PMID: 26516065
Psathas JN, Thomas-Tikhonenko A. MYC and the art of microRNA maintenance. Harb Perspect Med. 2014 Apr; 4(8). PMID: 24737842