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Results for Aberrant Splicing

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Peter S. Choi, PhD
Peter S. Choi Headshot

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

E-mail:
choip [at] chop.edu
Andrei Thomas-Tikhonenko, PhD
Andrei Thomas-Tikhonenko

Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.

E-mail:
thomastikhonenko [at] chop.edu

Science Stands Out in Our Most Engaging Cornerstone Stories of 2022

Published on
Dec 29, 2022
in Cornerstone Blog
Science Stands Out in Our Most Engaging Cornerstone Stories of 2022
These six Cornerstone stories garnered the most engagements from our CHOP Research Twitter, Facebook, and LinkedIn channels.

CHOP Researchers Elucidate Mechanism Behind Immunotherapy Resistance in B-ALL

Published on
Jan 24, 2022
in Cornerstone Blog
Researchers Find Mechanism of Treatment Resistance in B-ALL
Researchers identified aberrant splicing as a culprit behind treatment resistance in B-ALL.

Aberrant Splicing of CD22 in Acute Lymphoblastic Leukemia Underlies Resistance to Immunotherapy

Published on
Jan 4, 2022
in Press Releases
Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.

2019 Scientific Symposium Sparks Discussions on Big Data

Published on
May 29, 2019
in Cornerstone Blog
2019 Scientific Symposium
The 2019 Scientific Symposium focused on the advances CHOP researchers have made in the booming area of genomics and data science.

Choi Laboratory

Choi Lab

The Choi Laboratory is interested in the genetics of cancer and in particular, how genetic alterations affecting processes such as RNA splicing drive cancer and expose potential therapeutic vulnerabilities.

Thomas-Tikhonenko Laboratory

Thomas-Tikhonenko Lab

The Thomas-Tikhonenko Lab has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression.

1 - 8 of 8
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  • Roberts Individualized Medical Genetics Center (1)
  • Tasian Laboratory (1)
  • Thomas-Tikhonenko Laboratory (1)

In this section

Filter By

  • Principal Investigator / Faculty (2)

Organizations

  • Division of Cancer Pathobiology (4)
  • Center for Childhood Cancer Research (2)
  • Center for Computational and Genomic Medicine (2)
  • Department of Pathology and Laboratory Medicine (2)
  • Center for Applied Genomics (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Department of Biomedical and Health Informatics (1)
  • Department of Pediatrics (1)
  • Division of Allergy and Immunology (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Oncology (1)
  • Jolley Laboratory (1)
  • Mir Laboratory (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Roberts Individualized Medical Genetics Center (1)
  • Tasian Laboratory (1)
  • Thomas-Tikhonenko Laboratory (1)
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