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Results for Immunotherapy

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Evan Weber, PhD
Evan W. Weber

Dr. Weber is developing approaches to enhance CAR-T cell therapies for pediatric cancer by reprogramming T cells with improved durability and exhaustion resistance. His work will uncover molecular mechanisms that promote CAR-T cell exhaustion and identify new targets for therapeutic intervention.

E-mail:
weberew [at] chop.edu
Regina Myers, MD
Regina Myers

Dr. Myers aims to improve outcomes for children and young adults receiving cellular immunotherapies for high-risk hematologic toxicities. Her current research is focused on studying toxicities of CAR T-cell therapies through a combination of clinical epidemiologic and translational research methods.

E-mail:
myersrm [at] chop.edu
Jessica B. Foster, MD
Jessica B. Foster

Dr. Foster’s current research focuses on immunotherapy for pediatric solid and brain tumors. Specifically she is investigating chimeric antigen receptor (CAR) T cell therapy for neuroblastoma, high-grade gliomas, medulloblastomas, diffuse intrinsic pontine gliomas, and other brain tumors. The goals of her research are to develop pre-clinical CAR T cells for translation into clinical trials to help these devastating tumors.

E-mail:
fosterjb [at] chop.edu
Stephan A. Grupp, MD, PhD
Stephan A. Grupp

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

E-mail:
grupp [at] chop.edu
John M. Maris, MD
John M. Maris

Dr. Maris investigates the molecular and genetic mechanisms contributing to the development and progression of neuroblastoma, a common childhood cancer. He also aims to develop new molecular diagnostic tests and less toxic, targeted therapies to treat relapsed or refractory neuroblastoma, including a major effort in immunotherapy discovery and development.

E-mail:
maris [at] chop.edu
Leyuan Ma, PhD
Leyuan Ma

Dr. Ma focuses on immune engineering. He leverages genetic, chemistry, and engineering tools to dissect immune cell-cell and cell-tissue crosstalk and harness these crosstalk mechanisms to develop biomaterials, protein, and cell-based precision immunotherapies for cancer and autoimmune diseases.

E-mail:
mal5 [at] chop.edu
Hamid Bassiri, MD, PhD
Hamid Bassiri

Dr. Bassiri studies the ways in which the immunometabolic features of lymphocytes are altered within solid tumor environments, and how modulating these features may enhance anti-tumor immunity.

E-mail:
bassiri [at] chop.edu
David M. Barrett, MD, PhD
David M. Barrett

Dr. Barret's research program focuses on immune function of children with cancer. His research involves investigating possible immune deficiencies that result in children developing cancer and developing immune-based therapies for childhood cancer.

E-mail:
barrettd [at] chop.edu
Shannon L. Maude, MD, PhD
Shannon L. Maude

Dr. Maude focuses on novel therapies for high-risk and relapsed pediatric acute lymphoblastic leukemia (ALL). She aims to identify new pediatric ALL treatments that are more effective, less toxic, and exhibit fewer side effects than existing cancer therapies.

E-mail:
maude [at] chop.edu
Robert B. (Brad) Lindell, MD
Robert B. (Brad) Lindell, MD

Dr. Lindell’s research program is centered on the biology of critical illness in children with immune dysfunction. His current translational research is focused on pediatric septic shock and the development of multiple organ dysfunction syndrome (MODS) in critically-ill children.

E-mail:
lindellr [at] chop.edu
1 - 10 of 164

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In this section

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  • Principal Investigator / Faculty (19)
  • Researcher / Lab Personnel (1)

Organizations

  • Division of Oncology (37)
  • Center for Childhood Cancer Research (35)
  • Cancer Immunotherapy (CAR-T) (17)
  • Department of Pediatrics (15)
  • Center for Injury Research and Prevention (13)
  • PolicyLab (12)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (10)
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  • Food Allergy Center (4)
  • Lifespan Brain Institute (4)
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  • Mitochondrial Medicine (4)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Biomedical and Health Informatics (3)
  • Division of Adolescent Medicine (3)
  • Division of Human Genetics (3)
  • Immune Dysregulation Program (3)
  • Office of Academic Training and Outreach Programs (3)
  • Cell and Gene Therapy Collaborative (2)
  • Center for Data-Driven Discovery in Biomedicine (2)
  • Clinical Research Support Office (2)
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  • Thomas-Tikhonenko Laboratory (2)
  • Anderson Laboratory (1)
  • Arruda Laboratory (1)
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  • Center for Violence Prevention (1)
  • CHOP Microbiome Center (1)
  • Clinical Vector Core (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • DBHi Bioinformatics (1)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (1)
  • Department of Surgery (1)
  • Division of Emergency Medicine (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Nephrology (1)
  • Division of Ophthalmology (1)
  • Division of Plastic, Reconstructive and Oral Surgery (1)
  • Division of Rheumatology (1)
  • Division of Transplant Immunology (1)
  • Division of Urology (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Friedreich’s Ataxia Center of Excellence (1)
  • Genes, Genomics, and Pediatric Disease Affinity Group (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Jolley Laboratory (1)
  • Ma Laboratory for Immune Engineering (1)
  • mHealth Research Affinity Group (1)
  • Mir Laboratory (1)
  • Mossé Laboratory (1)
  • Novel Therapeutics for Bleeding Disorders (1)
  • Office of Research Compliance (1)
  • Office of Research Safety (1)
  • Office of the Ruth M. Colket Chair Pediatric Nursing Science (1)
  • Research Vector Core (1)
  • Tasian Laboratory (1)
  • Tsui Laboratory (1)
  • Vaccine and Treatment Evaluation Unit (1)
  • West Philadelphia Asthma Care (1)

In this section

Filter By

  • Principal Investigator / Faculty (19)
  • Researcher / Lab Personnel (1)

Organizations

  • Division of Oncology (37)
  • Center for Childhood Cancer Research (35)
  • Cancer Immunotherapy (CAR-T) (17)
  • Department of Pediatrics (15)
  • Center for Injury Research and Prevention (13)
  • PolicyLab (12)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (10)
  • Center for Autism Research (9)
  • Department of Pathology and Laboratory Medicine (9)
  • Center for Applied Genomics (8)
  • Center for Computational and Genomic Medicine (8)
  • Division of Infectious Diseases (8)
  • Children’s Oncology Group (6)
  • Clinical Futures (6)
  • Division of Cancer Pathobiology (6)
  • Division of Hematology (6)
  • Division of Allergy and Immunology (4)
  • Food Allergy Center (4)
  • Lifespan Brain Institute (4)
  • Maris Laboratory (4)
  • Mitochondrial Medicine (4)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Biomedical and Health Informatics (3)
  • Division of Adolescent Medicine (3)
  • Division of Human Genetics (3)
  • Immune Dysregulation Program (3)
  • Office of Academic Training and Outreach Programs (3)
  • Cell and Gene Therapy Collaborative (2)
  • Center for Data-Driven Discovery in Biomedicine (2)
  • Clinical Research Support Office (2)
  • Department of Radiology (2)
  • Division of Cardiology (2)
  • Division of Neonatology (2)
  • Division of Neurology (2)
  • Division of Orthopaedic Surgery (2)
  • Division of Pulmonary and Sleep Medicine (2)
  • Pennsylvania Pediatric Medical Device Consortium (2)
  • Roberts Individualized Medical Genetics Center (2)
  • Thomas-Tikhonenko Laboratory (2)
  • Anderson Laboratory (1)
  • Arruda Laboratory (1)
  • Bosse Laboratory (1)
  • Brain-Gene-Development Lab (1)
  • Center for Applied Genomics Laboratory (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for Pediatric Airway Disorders (1)
  • Center for Single Cell Biology (1)
  • Center for Spatial and Functional Genomics (1)
  • Center for Violence Prevention (1)
  • CHOP Microbiome Center (1)
  • Clinical Vector Core (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • DBHi Bioinformatics (1)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (1)
  • Department of Surgery (1)
  • Division of Emergency Medicine (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Nephrology (1)
  • Division of Ophthalmology (1)
  • Division of Plastic, Reconstructive and Oral Surgery (1)
  • Division of Rheumatology (1)
  • Division of Transplant Immunology (1)
  • Division of Urology (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Friedreich’s Ataxia Center of Excellence (1)
  • Genes, Genomics, and Pediatric Disease Affinity Group (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Jolley Laboratory (1)
  • Ma Laboratory for Immune Engineering (1)
  • mHealth Research Affinity Group (1)
  • Mir Laboratory (1)
  • Mossé Laboratory (1)
  • Novel Therapeutics for Bleeding Disorders (1)
  • Office of Research Compliance (1)
  • Office of Research Safety (1)
  • Office of the Ruth M. Colket Chair Pediatric Nursing Science (1)
  • Research Vector Core (1)
  • Tasian Laboratory (1)
  • Tsui Laboratory (1)
  • Vaccine and Treatment Evaluation Unit (1)
  • West Philadelphia Asthma Care (1)
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