Results for B-cell Receptor Pathway

1 - 5 of 5

Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.

E-mail:

thomastikhonenko [at] email.chop.edu

View Andrei Thomas-Tikhonenko's Profile

Kai Tan, PhD

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:

tank1 [at] email.chop.edu

View Kai Tan's Profile

Snapshot Science: Can Boosting an Oncogene Make Cancer Cells More Vulnerable to Chemotherapy?

Published on

May 1, 2019

in Cornerstone Blog

Oncogenes such as MYC are notorious troublemakers that promote cancer. Previous research strategies have focused on finding ways to quiet down levels of MYC; however, basic scientists at Children’s Hospital of Philadelphia took the opposite approach.

In the News: Emily Whitehead Anniversary, Buchanan Lectureship, Hyundai Young Investigators, Yi Xing, New York Auto Show

Published on

Apr 20, 2018

in Cornerstone Blog

Learn about new grants and awards for our cancer researchers in this week's edition of In the News.

Thomas-Tikhonenko Laboratory

The Thomas-Tikhonenko Lab has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, the lab’s studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.