Mechanistic Molecular Immunology Lab Publications

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Below is a list of selected publications from the Mechanistic Molecular Immunology Lab Publications. For all publications, visit Nikolaos G. Sgourakis, PhD list of publications on PubMed.

Overall SA, Toor JS, Hao S, Yarmarkovich M, Nguyen S, Japp AS, Moschidi D, Betts MR, Maris JM, Smibert P, Sgourakis NG. High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange. Nature Communications. 2020 Apr; 11:1909 PMID: 32312993
De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG. Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. Proc Natl Acad Sci USA. 2020 Mar; 117(13):7183-7192. PMID: 32184322
McShan AC, Devlin C, Overall SA, Park J, Toor JS, Moschidi D, Flores-Solis D, Choi H, Tripathi S, Procko E, Sgourakis NG. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. Proc Natl Acad Sci USA. 2019 Dec; 116 (51) 25602-25613. PMID: 31796585
McShan AC, Natarajan K, Kumirov K, Flores-Solis D, Jiang J, Badstubner M, Toor JS, Bagshaw CR, Kovrigin EL, Margulies DH, Sgourakis NG. Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle. Nature Chemical Biology. 2018 Jul; 14(8):811-820. PMID: 29988068
Toor JS, Rao AA, McShan AC, Yarmarkovich M, Nerli S, Yamaguchi K, Madejska AA, Nguyen S, Tripathi S, Maris JM, Salama SR, Haussler D, Sgourakis NG. A recurrent mutation in anaplastic lymphoma kinase with distinct neoepitope conformations. Frontiers in Immunology. 2018 Jan; 9:99. PMID: 29441070