Dr. Sgourakis’ research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells.
Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.
Dr. French came to CHOP in 2008 to establish the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics. She is an internationally recognized researcher involved in multi-investigator teams that utilize pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.
Dr. Cielo conducted clinical and translational research related to the mechanisms and effects of obstructive sleep apnea in children, with a specific focus on infant populations, children with craniofacial conditions, and the use of MRI and other imaging modalities to understand structural contributors to obstructive sleep apnea in children.
Dr. Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness. His multi-disciplinary research integrates brain imaging, genomics and clinical information.
Dr. Nah-Cederquist investigates solutions to clinical problems in pediatric plastic surgery. Her lab is built around the strengths of CHOP's clinical practices and basic science research. This offers the unique opportunity to directly test hypotheses born from clinical problems in the laboratory, and to take new technologies and concepts developed in the laboratory to patient care.
Dr. Zee's statistical methods research includes topics in survival analysis, measurement error, observational data methods, and machine learning. Her clinical research is focused on kidney disease, specifically in clinical and pathology markers of glomerular and chronic kidney disease progression.
Dr. Koyama's research focuses on Hereditary Multiple Exostoses (HME), a genetic disorder that causes the development of multiple benign tumors on the surface of the metaphyses of long bones. Based on his extensive knowledge of the normal processes of skeletal development and growth, Dr. Koyama's research aims to clarify the molecular mechanisms of HME formation and growth.
Dr. Krishnaswamy studies molecular mechanisms underlying the reactions of blood coagulation. His laboratory investigates how the proteins of blood coagulation interact with each other and with membranes to yield a regulated clotting response to vascular injury or an unregulated response in thrombotic or bleeding disease.