Center for Craniofacial Innovation



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Craniofacial surgery has a rich history at Children's Hospital of Philadelphia and the University of Pennsylvania Plastic Surgery. The Center for Craniofacial Innovation leverages key innovations in genomics, gene editing, and cell therapy to advance craniofacial and congenital conditions, and seeks to cultivate research programs with complementary strengths around the theme of craniofacial development and improving care of craniofacial conditions.

Scientists in the Center for Craniofacial Innovation study the basic and translational biology of craniofacial morphogenesis cranial neural and crest specification and development. We are also inherently interested in the basic biology of neural crest cell specification, migration, differentiation and potential for regeneration, and integrate the approaches of classical developmental and modern stem cell biology to explore human tissue regeneration and disease.

Our work will have a direct bearing on the discovery of drugs to mitigate malformation phenotypes and functional genomics of human candidate genes implicated in craniofacial disorders.

The fundamental lines of investigation in our center include molecular and cellular underlining of embryonic epithelial biology, epithelial mesenchymal transition, neural crest biology, gene regulatory networks, molecular basis of craniofacial morphogenesis, and the role of RNA alternative splicing in development and disease.

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