Since the completion of the Human Genome Project, there has been a natural surge in biomedical research aimed at gene discovery. Using genome-wide association studies (GWAS), bioinformatics, and other approaches, this process has focused largely on determining what genes are implicated in specific diseases.
The Center supports the planning of microbiome projects, DNA purification, library preparation, high-throughput sequencing, and bioinformatic analysis of the output.
Uncovering the correct functional context of genetic variants to translate genome-wide association studies into meaningful benefits for pediatric care.
The Lefebvre Lab advances the understanding of skeletal and neurodevelopmental syndromes. To this end, the team is decrypting mechanisms controlling the identity and activities of stem cells and differentiated cells governing these processes.
The work of scientists in the Center for Craniofacial Innovation will have a direct bearing on the discovery of drugs to mitigate malformation phenotypes and functional genomics of human candidate genes implicated in craniofacial disorders.
