Breath Biomarkers of Mitochondrial Dysfunction



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This prospective cohort study will compare breath biomarkers from subjects with mitochondrial disease to healthy controls. The age range for the study is 4-80 years and all subjects will be recruited at CHOP. Participation would consist of a one time visit, up to 2 hours maximum, to collect identifiable information and breath sample. The goal is to identify VOC biomarkers that characterize mitochondrial disease compared to healthy controls, which could lead to a non-invasive breath test for mitochondrial function. Subjects will be compensated as a form of appreciation for participating in the study. 

Who Do I Contact?

If you are interested in participating in the study or want to learn more please contact our study team at aryala [at] or 267-846-1196.

Eligibility & Criteria

IRB #:
Official Title:
Measuring In Vivo Mitochondrial Dysfunction Via Breath Analysis
Study Phase:
Eligible Age Range:
4 - 80 Years

Visit Criteria

One time visit up to 2 hours maximum to allow for collection of identifiable information and breath collection. 


Audrey R. Odom John, MD, PhD
Principal Investigator

Amalia Berna
Principal Investigator