Division of Infectious Diseases

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Infectious diseases are among the leading causes of disease globally and often complicate the care of patients with rare, complex, and chronic conditions. With the goal of preventing infections as well as optimizing the care of patients who do develop infection, researchers in the Division of Infectious Diseases study a wide variety of disease processes. High-impact research in the Division focuses on exploring novel therapeutics for cancers and infectious diseases based on immunomodulating strategies; understanding the interaction between the microbiome and the developing human immune system to identify tools to prevent autoimmunity and infectious diseases; developing a biorepository for high-risk pathogens so we can leverage the genetic composition of an organism to optimize therapeutic decisions for individual patients; and using epidemiologic and sociobehavioral studies to derive tools that will improve the population health of children, particularly with respect to optimal antibiotic therapy; and developing biomarkers to improve the diagnosis of rare and complex infectious diseases.

Fortifying the Division's research program are the Pediatric Infectious Disease Epidemiology and Antibiotic Stewardship (IDEAS) Research Team, which operates within the Center for Pediatric Clinical Effectiveness; robust programs in both basic and translational immunology and bacterial pathogenesis; strong collaboration with the Division of Oncology, with several faculty members holding joint appointments in both Divisions; a leadership role in the Children's Oncology Group; strong clinical and research collaborations with the Children's Hospital of Philadephia Infectious Diseases Research Laboratory, and close ties with the PennCHOP Microbiome Program at the University of Pennsylvania.