Biomedical Optical Devices to Monitor Cerebral Health

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Appropriate oxygenation strategies during critical illness and events such as cardiac arrest are essential to prevent brain injury and improve patients’ chances of good neurological outcome. Currently there are no methods available to monitor brain oxygen balance to help guide treatment, which represents a huge gap in care. This program seeks to develop a first-of-its-kind noninvasive device that monitors brain oxygen levels. Incorporating this device into lifesaving medical equipment such as defibrillators and circulatory pumps will ensure that patients receive treatment to maximize their brain oxygen levels, thus maximizing their quality of life upon recovery. 

Here are some highlights of the program’s research efforts:

  • Develop real-time measurements of cerebral blood flow and cerebral oxygen saturations
  • Develop a real-time algorithm with graphic-user interface that outputs oxygen balance for clinicians to act upon
  • Validate instruments and algorithms working with large mammal models
  • Translate this to human studies
  • Develop industry relationships for technology licensing

The Biomedical Optical Devices to Monitor Cerebral Health program received Frontier status for Fiscal Year 2020.