615 Civic Center Blvd.
Abramson Research Center
Philadelphia, PA 19147
Professor of Psychiatry
Graduate Group Affiliations
Cell and Molecular Biology
I am a Children's Hospital of Philadelphia-based faculty in the Department of Psychiatry at UPenn.
The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use life model genetics, forebrain slice and dissociated culture techniques, as well as life model pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination of subclasses of GABAergic interneurons implicated in the neuropathology of autism and schizophrenia. In addition, we are using life model stem cell-derived interneurons in life models of cell-based therapies for seizures, psychosis, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease.
For information related to ongoing research projects in the Anderson lab, please see https://stewandersonlab.research.chop.edu/
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
University of Connecticut, Storrs, CT, 1989.
Tischfield DJ, Kim J, Anderson SA: Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells. Stem Cell Reports 8(5): 1135-43, 2017.
Tischfield DJ, Saraswat DK, Furash A, Fowler SC, Fuccillo MV, Anderson SA.: Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiology of Disease 103: 174-183, 2017.
Donegan JJ, Tyson JA, Branch SY, Beckstead MJ, Anderson SA, Lodge DJ.: Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Mol Psychiatry. epub ahead of print, 2016.
Lin-Hendel EG, McManus MJ, Wallace DC, Anderson SA*, Golden JA*. (*co-corresponding authors): Differential mitochondrial requirements for radially and non-radially migrating cortical neurons: implications for mitochondrial disorders. Cell Reports in press, 2016.
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag AR, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nature Neuroscience 19(12): 1743-49, 2016.
Chu J, Anderson SA : Development of Cortical Interneurons. Neuropsychopharmacology 40(1): 16-23, 2015.
Jaiswal MK, Keros S, Zhao Z, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA : Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Frontiers in Cellular Neuroscience 9: 127-134, 2015.
Lia D, Takedaa N, Jaina R, Manderfielda LJ, Liu F, Lia L, Anderson SA*, Epstein, J* (*co-corresponding authors): Hopx distinguishes hippocampal from lateral ventricle neural stem cells and regulates neurogenesis. Stem Cell Research 15(3): 522-9, 2015.
Anderson SA, Parent JM (2015). : Reprogramming patient-derived cells to study the epilepsies. Nature Neuroscience 18(3): 360-366, 2015.
Tyson JA, Goldberg EM, Maroof AM, Xu Q, Petros TJ, Anderson SA.: Duration of culture and Sonic Hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development 142(7): 1267-78. 2015.