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mukhopadhs [at] chop.edu
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11th floor, Office 11214

2716 South Street
Philadelphia, PA 19146
United States

Sagori Mukhopadhyay, MD, MMSc
Sagori Mukhopadhyay
Attending Neonatologist

Dr. Mukhopadhyay’s research interests include neonatal infectious disease epidemiology, the developing microbiome and the effect of these early-life factors on later childhood health outcomes.

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Bio

Dr. Mukhopadhyay’s overall research goal is to understand effects of early-life factors on childhood outcomes. Her work has focused on the role of neonatal infections and antimicrobial therapy in altering early colonization with subsequent impact on health outcomes. Her work on epidemiology of neonatal infectious disease and early life antibiotic exposure with childhood atopy and obesity is funded by the National Institutes of Health (NICHD) and the Centers of Disease Control and Prevention. She has also received funding as part of the Physician Scientist Award from the Society of Pediatric Research and the Transdisciplinary Awards Program in Translational Medicine and Therapeutics from the University of Pennsylvania to determine differences in microbiome development trajectories in preterm infants based on early-life factors. She has led the recruitment of longitudinal birth cohorts in both healthy term and preterm population and created a repository of biospecimens and clinical databases. The ultimate aim of Dr. Mukhopadhyay’s work is to use the translational and epidemiological knowledge gained from these cohorts to drive targeted change in early life care that will promote better health outcomes for children throughout their lifespan.

Education and Training

MBBS, Burdwan University, India (2002)

MD, Rajasthan University, India (2006)

Residency, Boston Combined Residency Program, 2010

Fellowship, Harvard Neonatal-Perinatal Medicine Fellowship, 2013

MMSc, Harvard University, 2013

Titles and Academic Titles

Attending Neonatologist

Assistant Professor of Pediatrics

Professional Memberships

American Academy of Pediatrics, 2009-

Associate Editor, Pediatric Research, 2020-

Indian Academy of Pediatrics, 2004-

Philadelphia Perinatal Society, 2015-

Society for Pediatric Research, 2012-

Society of Pediatric Research Diversity Workgroup, 2020-

Vermont Oxford Network (Faculty), 2018

Professional Awards

Schliesman Committee Travel Grant, Children's Hospital Boston, 2010

Fredrick H Lovejoy, Jr. Award, Children's Hospital Boston, 2010

Von L. Meyer Traveling Award, Children's Hospital Boston, 2011

Best Clinical Research Presentation, Section on Perinatal Pediatrics, AAP 2011

Partners in Excellence Team Award, Brigham and Women's Hospital, 2014

University of Pennsylvania Health Systems Quality and Safety Awards, 2015

Physician - Scientist Award, Society for Pediatric Research 2017

Penn Medicine Quality and Patient Safety Overall Award, 2019

Publication Highlights

Underwood MA, Mukhopadhyay S, Lakshminrusimha S, Bevins CL. Neonatal intestinal dysbiosis. J Perinatol. 2020 Nov; 40(11):1597-1608. PMID: 32968220
Mukhopadhyay S, Wade KC, Dhudasia MB, Skerritt L, Chou JH, Dukhovny D, Puopolo KM. Clinical impact of neonatal hypoglycemia screening in the wellbaby care. J Perinatol. 2020 Sep; 40(9):1331-1338. PMID: 32152490
Garber SJ, Dhudasia MB, Flannery DD, Passarella MR, Puopolo KM, Mukhopadhyay S. Delivery-based criteria for empiric antibiotic administration among preterm infants. J Perinatol. 2020 Aug; Online ahead of print. PubMed PMID: 32792629
Kuzniewicz MW, Mukhopadhyay S, Li, S, Walsh E, Puopolo KM. Time to positivity of neonatal blood cultures for early-onset sepsis. Pediatr Infect Dis J. 2020 Jul; 39(7)634-640. PubMed PMID: 32379197
Mukhopadhyay Sc, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotton CM, Sánchez PJ, Bell EF, Eichenwald EC, Stoll BJ. Impact of early-onset sepsis and antibiotic use on death or survival with neurodevelopmental impairment at 2 years of age among extremely preterm infants. J Pediatr. 2020 Jun; 221:39-46. PubMed PMID: 32446491

Active Grants/Contracts

Incidence of atopy and childhood infections in uninfected term newborns with perinatal antibiotic exposure
NICHD
1K23HD088753
08/01/2017-07/31/2022
One-third of American babies are exposed to antibiotics around the time birth. The goal of this study is to assess the relationship of these antibiotic exposures to the development of early childhood allergy and infections. The results of this study may alter the perceived safety of prophylactic antibiotics and profoundly affect newborn clinical practice.
PI: Sagori Mukhopadhyay

Early Microbiome as a Marker of Prematurity Endotypes
University of Pennsylvania
Transdisciplinary Awards Program in Translational Medicine and Therapeutics
02/01/2020-01/31/2021
Prospective cohort study of preterm infants to identify microbiome pattern based on delivery characteristics.
PI: Sagori Mukhopadhyay

Early Life Antibiotics, Gut Microbiome and Risk of Childhood Obesity
NIAID
R01AI121383-01A1 (PI: Gerber)
04/1/16 – 03/31/21
The goal of this study is to define the impact of antibiotics administered during the intrapartum, neonatal and early infant periods on the constitution of the gut microbiome, and to determine the relationship to the development of childhood obesity.
CO-PI: Sagori Mukhopadhyay

Maternal and Neonatal Group B seroepidemiology
CDC
Centers for Disease Control and Prevention Broad Agency Announcement (PI: Puopolo)
09/30/2019- 12/28/2020
Multicenter Prospective cohort study to determine the prevalence of GBS specific antibodies in the women and their infants.
CO-PI:Sagori Mukhopadhyay

Links of Interest