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Dr. Mukhopadhyay’s research interests include neonatal infectious disease epidemiology, the developing microbiome and the effect of these early-life factors on later childhood health outcomes.
Dr. Mukhopadhyay’s overall research goal is to understand effects of early-life factors on childhood outcomes. Her work has focused on the role of neonatal infections and antimicrobial therapy in altering early colonization with subsequent impact on health outcomes. Her work on epidemiology of neonatal infectious disease and early life antibiotic exposure with childhood atopy and obesity is funded by the National Institutes of Health (NICHD) and the Centers of Disease Control and Prevention. She has also received funding as part of the Physician Scientist Award from the Society of Pediatric Research and the Transdisciplinary Awards Program in Translational Medicine and Therapeutics from the University of Pennsylvania to determine differences in microbiome development trajectories in preterm infants based on early-life factors. She has led the recruitment of longitudinal birth cohorts in both healthy term and preterm population and created a repository of biospecimens and clinical databases. The ultimate aim of Dr. Mukhopadhyay’s work is to use the translational and epidemiological knowledge gained from these cohorts to drive targeted change in early life care that will promote better health outcomes for children throughout their lifespan.
Education and Training
MBBS, Burdwan University, India (2002)
MD, Rajasthan University, India (2006)
Residency, Boston Combined Residency Program, 2010
Fellowship, Harvard Neonatal-Perinatal Medicine Fellowship, 2013
MMSc, Harvard University, 2013
Titles and Academic Titles
Assistant Professor of Pediatrics
American Academy of Pediatrics, 2009-
Associate Editor, Pediatric Research, 2020-
Indian Academy of Pediatrics, 2004-
Philadelphia Perinatal Society, 2015-
Society for Pediatric Research, 2012-
Society of Pediatric Research Diversity Workgroup, 2020-
Vermont Oxford Network (Faculty), 2018
Schliesman Committee Travel Grant, Children's Hospital Boston, 2010
Fredrick H Lovejoy, Jr. Award, Children's Hospital Boston, 2010
Von L. Meyer Traveling Award, Children's Hospital Boston, 2011
Best Clinical Research Presentation, Section on Perinatal Pediatrics, AAP 2011
Partners in Excellence Team Award, Brigham and Women's Hospital, 2014
University of Pennsylvania Health Systems Quality and Safety Awards, 2015
Physician - Scientist Award, Society for Pediatric Research 2017
Penn Medicine Quality and Patient Safety Overall Award, 2019
Incidence of atopy and childhood infections in uninfected term newborns with perinatal antibiotic exposure
One-third of American babies are exposed to antibiotics around the time birth. The goal of this study is to assess the relationship of these antibiotic exposures to the development of early childhood allergy and infections. The results of this study may alter the perceived safety of prophylactic antibiotics and profoundly affect newborn clinical practice.
PI: Sagori Mukhopadhyay
Early Microbiome as a Marker of Prematurity Endotypes
University of Pennsylvania
Transdisciplinary Awards Program in Translational Medicine and Therapeutics
Prospective cohort study of preterm infants to identify microbiome pattern based on delivery characteristics.
PI: Sagori Mukhopadhyay
Early Life Antibiotics, Gut Microbiome and Risk of Childhood Obesity
R01AI121383-01A1 (PI: Gerber)
04/1/16 – 03/31/21
The goal of this study is to define the impact of antibiotics administered during the intrapartum, neonatal and early infant periods on the constitution of the gut microbiome, and to determine the relationship to the development of childhood obesity.
CO-PI: Sagori Mukhopadhyay
Maternal and Neonatal Group B seroepidemiology
Centers for Disease Control and Prevention Broad Agency Announcement (PI: Puopolo)
Multicenter Prospective cohort study to determine the prevalence of GBS specific antibodies in the women and their infants.