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E-mail
kurrep [at] email.chop.edu
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Room 302D

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Peter Kurre, MD
Peter Kurre
Director, Comprehensive Bone Marrow Failure Center

Dr. Kurre's laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve the understanding of the progressive hematopoietic failure in patients with bone marrow failure and FA, broaden diagnostic approaches, and develop next generation therapies.

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Bio

As a physician-scientist, the clinical and scientific goals of Dr. Kurre's work are directed at improving understanding and broadening treatment options for patients with bone marrow failure.

Dr. Kurre's clinical interests focus on the diagnosis and treatment of bone marrow failure and specifically on improving diagnostic and therapeutic capabilities. Advances in genomic technologies provide exciting opportunities to streamline the frequently extended diagnostic work up of children with bone marrow failure. He and colleagues at other institutions are spearheading efforts to leverage molecular technologies toward the development of tests that improve diagnostic certainty and timeliness of genetic bone marrow failure. They are also developing clinical trials to enhance treatment and post treatment surveillance options.

Dr. Kurre's laboratory has longstanding expertise in Fanconi Anemia (FA), a rare inherited genetic condition with prominent hematologic complications, and he hopes to improve the understanding of the progressive hematopoietic failure that occurs in patients with FA. In addition to preclinical vector development for stem cell gene therapy, his more recent studies aim to reveal the origins of bone marrow failure in FA before birth. Studies in murine models of FA indicate that a significant portion of hematopoietic stem cells are lost prenatally and during infancy. Dr. Kurre's lab is developing strategies that will ameliorate those losses, with the long term goal of reversing the successive erosion of the stem cell pool in children. Additional projects in the lab are focused on stem cell regulation by trafficking of extracellular vesicles in the bone marrow microenvironment.

Notable career accomplishments to date include:

  • Definitive demonstration that hematopoietic deficits in FA arise during development
  • The first description of the role of vesicle trafficking in the development of cytopenias in acute myeloid leukemia
  • The development of preclinical protocols that minimize stem cell losses during lentivector transduction of FA hematopoietic stem cells

Education and Training

MD - RWTH Aachen University, Germany, 1991

Titles and Academic Titles

Director, Comprehensive Bone Marrow Failure Center

Buck Family Endowed Chair in Hematology

Professor of Pediatrics

Professional Memberships

American Society of Hematology, 2001-

American Society of Pediatric Hematology Oncology, 2003-

Society for Pediatric Research, 2006-

International Society for Extracellular Vesicles, 2011-

North American Pediatric Aplastic Anemia Consortium, 2013-

Professional Awards

Hyundai Scholar, Hyundai "Hope on Wheels" Foundation 2012, 2014-2017, 2018

Publication Highlights

Pubmed:
Doron B, Abdelhamed S, Butler JT, Hashmi SK, Horton TM, Kurre P. Transmissible ER stress reconfigures the AML bone marrow compartment. Leukemia. 2018 Sep; doi: 10.1038/s41375-018-0254-2. PMID: 30206307
Hornick NI, Doron B, Abdelhamed S, Huan J, Harrington CA, Shen, Cambronne XA, Chakkaramakkil VS, Kurre P. AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. Science Signal. 2016 Nov; 9(444):ra88. doi: 10.1126/scisignal.aaf2797. PMID: 27601730
Yoon YM, Storm KJ, Kamimae-Lanning AN, Goloviznina NA, Kurre P. Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2016 Nov; 7(5): 840-853. PMCID: PMC5106485
Chakkaramakkil VS, Goloviznina NA, Kurre P. Phenotypic correction of Fanconi anemia cells in the murine bone marrow after carrier cell mediated delivery of lentiviral vector. Stem Cell Res Ther. 2016 Nov; 7(1): 170, PMCID: PMC5116221
Gagne KE, Ghazvinian R, Yuan D, Zon RL, Storm K, Mazur-Popinska M, Andolina L, Bubala H, Golebiowska S, Higman MA, Kalwak K, Kurre P, Matysiak M, Niewiadomska E, Pels S, Petruzzi MJ, Pobudejska-Pieniazek A, Szczepanski T, Fleming MD, Gazda HT, Agarwal S. Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. Blood. 2014 Jul; 124(3): 437-40, PMCID: PMC4102714

Personal Interests

Cycling

Photography

Links of Interest