Comprehensive Bone Marrow Failure Center

Researchers at the Comprehensive Bone Marrow Failure Center are currently engaged in the following efforts:

• Kurre Laboratory: Understanding the cause of stem cell losses in Fanconi Anemia (FA); the role of FA proteins during hematopoietic development; and the role of cell-derived extracellular vesicles in stem cell regulation.
• Olson Laboratory: The role of germline genetic predisposition syndromes in the development of pediatric myelodysplastic syndrome and acute myeloid leukemia; patterns of HLA allele expression and clonal evolution in acquired aplastic anemia; investigation of how intrinsic pathways governing hematopoietic stem cell niche function can be harnessed to improve the efficiency and durability of donor engraftment after hematopoietic stem cell transplantation; clinical trials of novel conditioning and T cell depletion strategies to improve survival and decrease allo-immune complications for patients with non-malignant hematologic disorders undergoing hematopoietic stem cell transplantation.
• Babushok Laboratory: Clonal evolution in acquired and inherited BMF syndromes; mechanisms of autoimmunity in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.