Dr. Gadue studies cell fate decisions, focusing on endoderm and mesoderm specification using human ES and iPS cells. Their unique characteristics to differentiate and be propagated almost indefinitely lead to the exciting prospect of using these cells to study disease processes and developmental pathways in vitro and eventually to treat a wide variety of diseases using cell replacement therapies.

One area of interest in Dr. Gadue's lab involves investigating hematopoiesis with a focus on megakaryocyte development. Dr. Gadue is studying the molecular pathways that regulate megakaryopoeisis with the goal of optimizing the generation of platelets in vitro from ES/iPS cells. In addition, the lab is developing in vitro models of platelet disorders using iPS cells derived from patients with genetic diseases affecting platelet development and function.

Endoderm formation is Dr. Gadue's second area of research interest, and this line of investigation involves studying a unique endodermal stem cell population the lab generated from human ES and iPS cells. He is specifically studying the signaling and transcriptional pathways which regulate endoderm stem cell generation and maintenance.

Dr. Gadue is also using the endodermal stem cell population as a model to study pancreatic beta cell specification with the goal of generating functional beta cells from human ES and iPS cells. Lastly, he is using the stem cell system to model genetic forms of diabetes.

BSc, University of Rochester (Cell and Developmental Biology), 1995

PhD, University of Pennsylvania (Immunology), 2002

Fellowship, Mt. Sinai School of Medicine (Embryonic Stem Cell Biology), 2008

Associate Director, Human Embryonic Stem Cell Core

Investigator

Associate Professor of Pathology and Laboratory Medicine

Goldie Simon Preceptorship Award, Lupus Foundation of Southeastern Pennsylvania, 2002

Ruth L. Kirschstein National Research Service Award, 2003