Dr. Lisa M. Guay-Woodford is an internationally recognized pediatric nephrologist whose work focuses on identifying clinical and genetic factors involved in the pathogenesis of inherited renal disorders, most notably autosomal recessive polycystic kidney disease (ARPKD). Her laboratory participated in the identification of the human ARPKD gene as part of an international consortium and her group was the first to identify a candidate modifier gene for ARPKD.

Dr. Guay-Woodford directed the NIDDK-funded Hepato-Renal Fibrocystic Disease Research and Translational Core Center, initially established when she was at the University of Alabama at Birmingham (UAB), and she continues to serve as co-director of the UAB Childhood Cystic Kidney Disease Core Center. Her research program has been funded by the NIH, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, and the Polycystic Kidney Disease Foundation. In 2009, Dr. Guay-Woodford was awarded the Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease, given by the PKD Foundation and the International Society of Nephrology.

Dr. Guay-Woodford is the senior advisor for Clinical and Translational Research Initiatives and director of the Inherited Renal Diseases Program at Children’s Hospital of Philadelphia, where she holds an endowed chair as a presidential professor in the Department of Pediatrics at the Perelman School of Medicine of the University of Pennsylvania.

MD, Harvard Medical School, 1983

Residency, Boston Children’s Hospital

Fellowship, Boston Children's Hospital

Senior Advisor for Clinical and Translational Research Initiatives

Director, Inherited Renal Diseases Program

Professor of Pediatrics

American Society of Nephrology, 1989-

American Society of Pediatric Nephrology, 1989

International Society of Nephrology, 1990-

International Pediatric Nephrology Association, 1990-

Councilor, 2001-2007

Pediatric Academic Societies, 2003

Society for Pediatric Research, 2003

Association for Clinical and Translational Science, 2008

Association of American Physicians, 2009

American Pediatric Society, 2013

Burroughs Wellcome Clinical Scientist Award in Translational Research, 2001

Executive Leadership in Academic Medicine (ELAM), 2005

Best Doctors in America, 2009, 2012, 2015, 2018, 2021

Lilian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease, 2009

Women in Pediatric Academic Medicine Award (WIPAM), University of Oklahoma, 2009, 2016

Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics
National Institute of Diabetes and Digestive and Kidney Diseases
2020 - 2025
The major goal of this project is to determine how FPC-CTD related Myc transcriptional regulation contributes to reno-protection in mouse Pkhd1 models; and 2) identify putative mechanisms that allow mouse renal epithelia to compensate for the loss of FPC-CTD nuclear function
PI: Lisa Guay-Woodford

UAB Childhood Cystic Kidney Disease Core Center (CCKDCC) Core A
National Institute of Diabetes and Digestive and Kidney Diseases
2020 - 2025
The major goal of this project is to understand the pathophysiology of cystic kidney disease in children.
PI: Bradley Yoder, co-PI: Lisa Guay-Woodford