Mir Laboratory

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The Mir Lab has opportunities to apply advanced microscopy methods to study transcription regulation and nuclear organization in developing embryos, develop new advanced microscopy, develop new ways to analyze large imaging datasets, combinations of the above, and more. We welcome postdoctoral researchers, biomedical graduate students, and undergraduate researchers. Please contact mirm@chop.edu.

The goal of the Mir Lab is to comprehend and manipulate the interplay between nuclear organization, transcription regulation, and gene expression patterns during cell-fate determination in developing embryos. We use a combination of advanced imaging technology, biophysical modeling, genomics, and gene editing. We are also especially interested in the interactions between the disordered regions of proteins and their role in driving functional nuclear organization. We develop and utilize new microscopy technologies and analysis tools that allows us to probe and bridge the broad range of spatial and temporal scales involved in gene regulation during embryonic development, ranging from single molecule kinetics at nanometer scales to patterning across embryos at millimeter scales.

​Our vision is to utilize quantitative data in combination with mechanistic modeling to develop new strategies to specifically manipulate nuclear organization and transcriptional regulation to achieve desired phenotypes. The insights gained through these projects will not only lead to an improved understanding of one of life’s fundamental processes - transcription - but also has the potential to lead to new technologies for treating conditions associated with aberrant gene expression.

 

Research Highlights

Leader

Mustafa Mir, PhD

Principal Investigator
Dr. Mir develops and applies advanced fluorescence microscopy and single molecule imaging methods to study the dynamics of nuclear organization and transcriptional regulation during early embryonic development.