Lindell Laboratory Research Overview

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The Lindell Lab's current projects aim to improve outcomes for patients with pediatric sepsis.

This project employs a suite of translational immunology lab assays to identify latent subclasses of disease in pediatric sepsis patients based on cellular immune responses and inflammatory proteomics, associate these candidate immunotypes with clinical outcomes, and then investigate the molecular mechanisms of one candidate immunotype identified through our preliminary data. Dr. Lindell serves as principle investigator for LIONS. The LIONS study is funded by NIH K12HD047349.

The goal of this project is to build a prospective, longitudinal human biorepository of human plasma and peripheral blood mononuclear cells derived from children with multiple organ dysfunction syndrome. These biospecimens will allow for identification of disease-specific immunotypes using cellular and molecular immune profiling assays. Dr. Lindell serves as principle investigator for PARADIGM-SHIFT. The PARADIGM-SHIFT study is supported by the Thrasher Research Fund, the CHOP Research Institute, and institutional startup funds.

The goal of this project is to develop an annotated biorepository of human biospecimens and feature-rich electronic health record-derived data from pediatric patients with suspected sepsis in the emergency department. In the subsequent R33 phase, the cohort to two additional centers and perform immune profiling assays. Dr. Lindell serves as co-investigator for this study. This study is funded by NIH R21GM146159.

PARADIGM is a 22-center prospective study of disease-, treatment-, and genomic-based risk factors for severe innate immune failure (immunoparalysis) in the setting of pediatric MODS. Dr. Lindell serves as site PI for PARADIGM at CHOP. The PARADIGM study is funded by NIH R01HD095976.

TROPICS is a prospective observational study of pediatric septic shock which seeks to use machine learning to identify factors which should guide packed red blood cell (PRBC) transfusion decision making and identify immune phenotypes that predict differential response to PRBC transfusion. Dr. Lindell serves as site PI for TROPICS at CHOP. The TROPICS study is funded by NIH R01HL157208.