Dr. Puopolo helped lead the research team that developed and validated multivariate prediction models for neonatal early-onset sepsis risk assessment. Her current research addresses the impacts of maternal immunity, perinatal antibiotic exposure, and neonatal infection on infant and childhood health.
Dr. Lindell’s research program is centered on the biology of critical illness in children with immune dysfunction. His current translational research is focused on pediatric septic shock and the development of multiple organ dysfunction syndrome (MODS) in critically-ill children.
Dr. Srinivasan is an attending neonatologist with the Pediatric Sepsis Program and the Division of Neonatology at Children's Hospital of Philadelphia. Her research focuses on biomarkers in neonatal inflammation and infection; and improving prediction, recognition and management of neonatal infections.
Dr. Perate is an anesthesiologist with a specialty in Neuroanesthesia at Children's Hospital of Philadelphia, an associate director with the CHOP Trauma Center, and an assistant professor of Clinical Anesthesiology and Critical Care. Dr. Perate's research focuses on sepsis and adaptive immunity.
The research interests of Dr. Downes focus on antimicrobial clinical pharmacology and pharmacoepidemiology in children with a goal to identify novel approaches to optimize efficacy, minimize toxicity, and limit antimicrobial resistance from antibiotics.
Dr. Thomas is a pediatric neuropsychologist with research interests in the neuropsychological effects of medical conditions including leukodystrophies and other neurologic disease, pediatric sepsis, neurodermatoses, cardiac conditions, genetic disorders, and rheumatic and endocrine disorders.
Dr. Coffin’s research interests focus on the epidemiology and prevention of healthcare-associated infections in the pediatric population. She also investigates the epidemiology of pediatric respiratory viral infections, with a particular emphasis on influenza.
Dr. Woods-Hill researches diagnostic and treatment decision-making in the critical care setting, with a specific interest on the impact of these decisions on unintended patient harm and medical overuse. She focuses on bacterial bloodstream infections in children in the PICU, and diagnostic stewardship in this context.
Dr. Silverman studies the fundamental aspects of early-life commensal microbes that influence immune system development and function. He discovered that the MHC-II E molecule prevents type 1 diabetes by shaping the intestinal microbiota early in life.