Almasy Lab Research Overview



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The Almasy Lab uses computational approaches to study the contribution of genetic factors to the etiology of complex disorders and neuropsychiatric phenotypes across the lifespan. Below is an overview of the lab's research.

CNVs and Major Psychopathology (CAMP)

Together with investigators at Boston Children's Hospital and the University of Montreal, the Almasy Lab is examining the effects of both rare and common genetic variation on psychosis, mood, developmental disorders, and cognitive ability in a sample of approximately 750,000 individuals as part of the NIMH-funded Genes to Mental Health Network.

Collaborative Study on the Genetics of Alcoholism (COGA)

The lab is studying genetic influences on electrophysiological endophenotypes associated with alcohol use disorders through COGA, an NIAAA-funded multi-site collaborative project.

Genetic influences across the lifespan

The Almasy Lab's work includes projects looking at how the action and impact of genetic factors varies across the lifespan, including studies of neurodevelopment (such as the Philadelphia Neurodevelopmental Cohort), aging, and genotype-by-age interaction.

Autism Spectrum Program of Excellence (ASPE)

With the Penn ASPE program, members of the lab are investigating dimensional measures of behavior, cognition, social function, sleep, and activity in families of individuals with autism and in families carrying mutations in the gene NRXN1.

Statistical genetic methods development

The lab develops, evaluates, and compares statistical genetic approaches for identification and characterization of genetic effects on common, complex traits. Part of this work takes places through organization of the Genetic Analysis Workshop, an international forum for statistical genetic methods development.