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Zackular Laboratory
We are hiring!
We are looking for highly motivated graduate students, postdoctoral fellows, and undergraduate researchers. Check out our latest work defining the impact of enterococci on C. difficile infection, published in Nature. If you are interested in our work and would like to join the team, please reach out to Dr. Zackular directly.
The long-term goal of the Zackular Lab is to understand how interactions between the host, gut microbiota, and pathogenic microbes impact human health and disease. At the center of their research is the important nosocomial pathogen, Clostridium difficile.
Over the past decade, incidence, severity, and costs associated with C. difficile infection (CDI) have increased dramatically. The primary risk factor for CDI is antibiotic treatment, which disrupts the resident gut microbiota and leads to susceptibility to C. difficile. Interestingly, non-antibiotic associated CDI cases are on the rise, suggesting that unexplored host, environmental, and microbiota factors likely influence CDI.
This research team is interested in identifying these environmental factors and defining underlying mechanisms of microbiota disruption and modulation of disease.
