VOCAL Trial

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This is a study to measure the effectiveness of the medication voclosporin compared to placebo in adolescent patients with active lupus nephritis. Volcosporin is an outpatient, oral medication.

Who Do I Contact?

If you are interested in participating in the study or want to learn more please contact our study team at RRC [at] CHOP.EDU or 267-426-8726.

Eligibility & Criteria

IRB #:
22-020575
Official Title:
A Double-Blind, Placebo-Controlled, Dose Escalation Study to Assess the Efficacy, Safety and Pharmacokinetics of Voclosporin in Adolescents with Lupus Nephritis
Study Phase:
Phase III
Eligible Age Range:
12 - 18 Years
Gender:
All
Study Categories:

Visit Criteria

Along with taking voclosporin, participants will also:
  • Provide blood and urine samples
  • Complete physical exams
  • Complete an ECG (electrocardiogram) 
  • Complete questionnaires and a disease activity assessment
  • Take MMF (mycophenolate mofetil)/oral corticosteroids 
  • Have methylprednisolone administration
  • Have medical record review(s)
Participation will last for 24 weeks and will involve 14 study visits.
 

Leader

Jon Burnham