Mitochondria | CHOP Research Institute
 

Mitochondria

Lindsay Festa, PhD
Lindsay Festa, PhD

Dr. Festa works to understand the molecular mechanisms underpinning normal neurodevelopment with a specific focus on white matter. She also focuses on discovering new therapeutic targets to restore or prevent white matter injury across a number of different pediatric neurologic conditions.

E-mail:
festal1 [at] chop.edu
Cornerstone Blog

Can Medication Improve Blood-Brain Barrier Function in 22q Deletion Syndrome?

Published on
Nov 5, 2025
Mitochondria in brain endothelial cells
Targeting the mitochondria improved blood-brain barrier function and cognition in a preclinical model of the genetic disorder.
Cornerstone Blog

CHOP-Penn Autism Experts Share Vision for Accelerated Discovery

Published on
Jun 3, 2024
Joseph W. St. Geme, MD, chair, Department of Pediatrics at CHOP; Lisa Guay-Woodford, MD, senior advisor for Clinical and Translational Research Initiatives at CHOP; and Benjamin Prosser, PhD, director, Center for Epilepsy and Neurodevelopmental Disorders
The CHOP-Penn Autism Research Symposium explored opportunities for breakthroughs in the understanding and treatment of autism spectrum disorder.
Cornerstone Blog

Holveck Family Gift Expedites Research for Rare Cancers

Published on
Nov 16, 2023
Through the Connor Initiative, CHOP researchers are working to unlock novel therapies that will change the standard of care for osteosarcoma.
The Connor Initiative, a multimillion dollar gift from the Holveck Family, will support precision therapeutics for osteosarcoma and rare cancers.
Cornerstone Blog

Researchers Study Mitochondrial Variation in Predisposition to Alzheimer’s Disease

Published on
Nov 13, 2023
Mitochondrial Dysfunction and Alzheimer’s Disease
Douglas C. Wallace, PhD, investigates the role of adaptive immunity in the etiology of Alzheimer’s disease (AD) and AD-related dementias.
Cornerstone Blog

PKIDS, Huntington’s Disease, Climate Change, Virtual Driving Assessments

Published on
Oct 13, 2023
In The News: PKIDS, Huntington’s Disease, Climate Change
In our weekly news roundup, Dr. Beverly Davidson received a $1 million grant to study Huntington’s disease. This and more on Cornerstone.
Cornerstone Blog

Vaccination in Higher Ed, New Genetic Disease, Concussions, Zebrafish

Published on
Sep 29, 2023
In The News: Vaccination, Genetics, Concussions, Zebrafish
This week’s In The News reports on higher education vaccination policies, college athletes’ concussions, a new genetic disease, and zebrafish.
Cornerstone Blog

FDA Approval, Mitochondrial Dysfunction, Pediatric Headaches

Published on
Aug 18, 2023
In the News: FDA Approval, Mitochondrial Dysfunction
The FDA approved an oral drug, based on foundational research conducted at CHOP, to treat a rare, severe bone disease. More In The News.
Cornerstone Blog

Tableside Chat About Mitochondria Leads to Gates Foundation Grant for COVID-19 Research

Published on
Mar 2, 2023
Tableside Chat Leads to Gates Foundation Grant for CHOP
With a grant from the Gates Foundation, CHOP researchers are working to determine the importance of mitochondria DNA variation in COVID-19 severity.
Cornerstone Blog

Environmental Hazards, Physician of the Year, Lifetime Achievement Award, Special Podcast Series

Published on
Apr 1, 2022
In the News
Learn about earn about a regional research collaboration, prestigious awards, and listen to a special podcast series.