Mitochondria | CHOP Research Institute


Published on
Aug 18, 2023
The FDA approved an oral drug, based on foundational research conducted at CHOP, to treat a rare, severe bone disease. More In The News.
Published on
Mar 2, 2023
With a grant from the Gates Foundation, CHOP researchers are working to determine the importance of mitochondria DNA variation in COVID-19 severity.
Published on
Dec 27, 2022
Featured Diversity Fellow Arnold Olali, PhD, is focused on understanding how mitochondria affect overall health.
Published on
Apr 1, 2022
Learn about earn about a regional research collaboration, prestigious awards, and listen to a special podcast series.
Published on
Sep 22, 2021
Marni Falk, MD, and Adam Resnick, PhD, to lead the Mitochondria and Cancer Connections (MC²) Research Program, a new CHOP research initiative.

The Wallace Laboratory investigates the role of mitochondria in human evolution, health, and disease.

The McCormack Lab studies the intersection of neuroendocrinology and metabolism, with two areas of focus. First, the lab studies genetic disorders with increased risk for diabetes mellitus, including mitochondrial diseases. Second, investigators in the lab focus on brain tumor-related hypothalamic obesity syndrome.

The research objectives of the Ischiropoulos Lab are to elucidate the nitric oxide signaling pathways at the proteome level in the cardiovascular and neuronal systems; define the molecular mechanisms by which nitric oxide signaling regulates metabolic pathways during development and aging; and develop and test novel therapeutics for long-chain f

Converging individualized basic, translational, and clinical research programs dedicated to improving the health of patients of all ages living with mitochondrial disease.

The Kilbaugh Lab focuses on advanced therapies for treating cardiac arrest, traumatic brain injuries, cardiopulmonary bypass, extracorporeal life support, defense against chemical toxins, and therapeutics for mitochondrial disorders that reduce neurological damage.