Hermansky-Pudlak Syndrome | CHOP Research Institute

Marks Laboratory

The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases.

Lisa R. Young, MD

Dr. Young’s translational research program aims to understand mechanisms underlying interstitial and rare lung diseases and develop new strategies to treat these disorders. Her laboratory focuses on the roles of epithelial cells in alveolar homeostasis, injury, and repair.

E-mail:

youngL5 [at] chop.edu

Michael S. Marks, PhD

Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.

E-mail:

marksms [at] chop.edu

Q&A With New AAAS Fellow Michael Marks: Curiosity, Collaborators, and Good Questions

Published on

Feb 21, 2017

in Cornerstone Blog

Cell biologist Michael Marks, PhD, studies strange, specific organelles that are only found in certain cell types in our bodies. By dissecting the ways these lysosome-related organelles are assembled, he has gained novel insights into how these mechanisms are thwarted in a rare genetic disease called Hermansky-Pudlak syndrome (HPS). The American Association for the Advancement of Science (AAAS) honored his

Platelet Granule Formation Gives Insight Into Rare Disease

Published on

Jul 23, 2014

in Cornerstone Blog

Cell biologists at The Children’s Hospital of Philadelphia Research Institute speculate that platelet granules hold the key to unlocking the mechanisms behind Hermansky-Pudlak syndrome.