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Jeffrey D. Roizen, MD, PhD, FAAP
Attending Physician
Dr. Roizen's research program aims to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity.
Bio
The goal of Dr. Roizen's research program is to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity. Toward this goal he employs a diverse toolbox of methods using large human data sets and mouse physiology combined with high throughput sequencing to drive questions in cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans.
Additionally, Dr. Roizen relies on core principles of improv to drive his scientific pursuits: listening, following the facts, finding what is interesting, being specific in scientific questions and hypotheses, and recognizing that for well-designed experiments there are no failures.
Education and Training
BA, Williams College (Chemistry and Biology), 2000
PhD, Washington University (Molecular and Cell Biology), 2008
MD, Washington University, 2008
Fellowship, Children's Hospital of Philadelphia (Pediatric Endocrinology), 2013
Titles and Academic Titles
Attending Physician
Assistant Professor of Pediatrics
Assistant Professor of Cell and Molecular Biology
Professional Memberships
Endocrine Society, 2006-
Pediatric Endocrine Society, 2010-
American Society for Bone and Mineral Research, 2012-
American Academy of Pediatrics, 2012
Philadelphia Endocrine Society, 2013-
American Diabetes Association, 2014-
International Osteoporosis Society, 2015-
American Society of Human Genetics, 2016-
American Society for Cell Biology, 2017-
Professional Awards
PES Travel Award (to PAS conference), Pediatric Endocrine Society, 2011
ASBMR Young Investigator Award, American Society for Bone and Mineral Research, 2011
Presidential Poster Award, American Society for Bone and Mineral Research, 2012
Endocrine Young Investigator Award, Endocrine Society, 2012
Endocrine Scholars Research Fellowship, Endocrine Society, 2013
Pediatric Endocrine Society Research Fellowship, Pediatric Endocrine Society, 2013
Distinguished Abstract Award, American Association for Clinical Chemistry, 2013
Late Breaking Abstract, Endocrine Society, 2014
International Society of Endocrinology Travel Award, International Society of Endocrinology, 2014
Clinical Practice Enhancement and Anesthesia Research Foundation Early Career Research Fellowship Award, Clinical Practice Enhancement and Anesthesia Research Foundation, 2014
Outstanding Clinical Research Poster, UPenn, Institute for Diabetes, Obesity and Metabolism , 2015
Pediatric Endocrine Society Clinical Scholar Research Fellowship Award, Pediatric Endocrine Society, 2015
ASBMR Early Investigator Travel Award, American Society of Bone and Mineral Research, 2015
Endocrine Society Early Investigator Award, Endocrine Society, 2016
McCabe Fund Pilot Award, McCabe Fund, University of Pennsylvania, 2016
Reviewers Choice Award, ASHG Annual Meeting, 2016
Innovative Approach Research Fellowship Award, Juvenile Diabetes Research Foundation, 2017
Penn Pathways Faculty Scholar, 2017, 2018
Young Investigators Award, International Vitamin D Workshop, 2018
ASBMR Rising Star Award, American Society of Bone and Mineral Research, 2018
Publication Highlights
PubMed:
Roizen JD, Long C, Casella A, O'Lear L, Caplan I, Lai M, Sasson I, Singh R, Makowski AJ, Simmons R, Levine M. Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D. Bone Min Res. 2019 Feb; e3686. PMID: 30790351
Roizen JD, Li D, O’Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda, CP, Thummel KE, Thacher TD, Hakonarson H, and Levine MA. CYP3A4 mutation causes vitamin D-dependent rickets type 3. J Clin Invest. 2018 May; 128(5):1913-1918. PMCID: PMC5919884
Xi D, Long C, Lai M, Casella A, O’Lear L, Kublaoui B, Roizen JD. Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response. J Endocr Soc. 2017 Jul; 1(8):1041-1055. PMID: 29264556
Roizen JD, Hysinger EB, Mentch FD, Vazquez L, Connolly JJ, Bradfield JP, Almoguera B, Sleiman PM, Allen JL, Levine MA, Hakonarson H. Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma. J Allergy Clin Immunol. 2016 Dec; 138(6):1747-1749.e4. PMCID: PMC5526345
Roizen JD, Danzig J, Groleau V, McCormack S, Casella A, Harrington J, Sochett E, Tershakovec A, Zemel BS, Stallings VA, Levine MA. Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clinical Endocrinol Metab. 2016 Mar; 101(3):880-8. PMCID: PMC4803160