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E-mail
roizenj [at] chop.edu
Location - People View
Room 510C

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Jeffrey D. Roizen, MD, PhD, FAAP
Jeffrey D. Roizen
Attending Physician

Dr. Roizen's research program aims to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity.

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Bio

The goal of Dr. Roizen's research program is to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity. Toward this goal he employs a diverse toolbox of methods using large human data sets and mouse physiology combined with high throughput sequencing to drive questions in cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans.

Additionally, Dr. Roizen relies on core principles of improv to drive his scientific pursuits: listening, following the facts, finding what is interesting, being specific in scientific questions and hypotheses, and recognizing that for well-designed experiments there are no failures.

Education and Training

BA, Williams College (Chemistry and Biology), 2000

PhD, Washington University (Molecular and Cell Biology), 2008

MD, Washington University, 2008

Fellowship, Children's Hospital of Philadelphia (Pediatric Endocrinology), 2013

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics

Assistant Professor of Cell and Molecular Biology

Professional Memberships

Endocrine Society, 2006-

Pediatric Endocrine Society, 2010-

American Society for Bone and Mineral Research, 2012-

American Academy of Pediatrics, 2012

Philadelphia Endocrine Society, 2013-

American Diabetes Association, 2014-

International Osteoporosis Society, 2015-

American Society of Human Genetics, 2016-

American Society for Cell Biology, 2017-

Professional Awards

PES Travel Award (to PAS conference), Pediatric Endocrine Society, 2011

ASBMR Young Investigator Award, American Society for Bone and Mineral Research, 2011

Presidential Poster Award, American Society for Bone and Mineral Research, 2012

Endocrine Young Investigator Award, Endocrine Society, 2012

Endocrine Scholars Research Fellowship, Endocrine Society, 2013

Pediatric Endocrine Society Research Fellowship, Pediatric Endocrine Society, 2013

Distinguished Abstract Award, American Association for Clinical Chemistry, 2013

Late Breaking Abstract, Endocrine Society, 2014

International Society of Endocrinology Travel Award, International Society of Endocrinology, 2014

Clinical Practice Enhancement and Anesthesia Research Foundation Early Career Research Fellowship Award, Clinical Practice Enhancement and Anesthesia Research Foundation, 2014

Outstanding Clinical Research Poster, UPenn, Institute for Diabetes, Obesity and Metabolism , 2015

Pediatric Endocrine Society Clinical Scholar Research Fellowship Award, Pediatric Endocrine Society, 2015

ASBMR Early Investigator Travel Award, American Society of Bone and Mineral Research, 2015

Endocrine Society Early Investigator Award, Endocrine Society, 2016

McCabe Fund Pilot Award, McCabe Fund, University of Pennsylvania, 2016

Reviewers Choice Award, ASHG Annual Meeting, 2016

Innovative Approach Research Fellowship Award, Juvenile Diabetes Research Foundation, 2017

Penn Pathways Faculty Scholar, 2017, 2018

Young Investigators Award, International Vitamin D Workshop, 2018

ASBMR Rising Star Award, American Society of Bone and Mineral Research, 2018

 

Publication Highlights

Roizen JD, Long C, Casella A, O'Lear L, Caplan I, Lai M, Sasson I, Singh R, Makowski AJ, Simmons R, Levine M. Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D. Bone Min Res. 2019 Feb; e3686. PMID: 30790351
Roizen JD, Li D, O’Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda, CP, Thummel KE, Thacher TD, Hakonarson H, and Levine MA. CYP3A4 mutation causes vitamin D-dependent rickets type 3. J Clin Invest. 2018 May; 128(5):1913-1918. PMCID: PMC5919884
Xi D, Long C, Lai M, Casella A, O’Lear L, Kublaoui B, Roizen JD. Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response. J Endocr Soc. 2017 Jul; 1(8):1041-1055. PMID: 29264556
Roizen JD, Hysinger EB, Mentch FD, Vazquez L, Connolly JJ, Bradfield JP, Almoguera B, Sleiman PM, Allen JL, Levine MA, Hakonarson H. Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma. J Allergy Clin Immunol. 2016 Dec; 138(6):1747-1749.e4. PMCID: PMC5526345
Roizen JD, Danzig J, Groleau V, McCormack S, Casella A, Harrington J, Sochett E, Tershakovec A, Zemel BS, Stallings VA, Levine MA. Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clinical Endocrinol Metab. 2016 Mar; 101(3):880-8. PMCID: PMC4803160