Division of Endocrinology and Diabetes

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Genetic and environmental influences have profound effects on the growth and development of a fetus and child, and those effects by extension have a tremendous impact on the health of the nation overall.

Research in the Division of Endocrinology and Diabetes at Children’s Hospital of Philadelphia leads the way in understanding the delicate balance between the genetic, epigenetic, and environmental impacts on the development of endocrine disease, and identifies potential solutions that are informed not only by scientific understanding but public values as well.

To that end, clinical and translational research in the Division focuses on the natural history and interventional trials in type 1 and type 2 diabetes; pediatric thyroid cancer; mechanisms of disease and pathophysiology of hyperinsulinism, as well as novel therapies for hyperinsulinism; epigenetic, environmental and inflammatory mediators of insulin resistance; metabolic bone disease and parathyroid disorders; health care disparities; mitochondrial regulation of bioenergetics; and CNS-mediated obesity.

Extramural-funded basic science research programs investigate the molecular genetic control of parathyroid cell biology and PTH action; pancreatic beta cell physiology and development; thyroid neoplasia; genetic control of vitamin D activation; and regulation of mineralization.