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E-mail
blobel [at] email.chop.edu
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Room 316H

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Gerd Blobel, MD, PhD
Gerd Blobel
Investigator

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

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Bio

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. One of the gene clusters he focuses on is the beta-globin locus and its associated diseases, such as sickle cell disease and thalassemia. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities.

In addition, Dr. Blobel is interested in the nuclear architecture, and genetic and epigenetic control of gene expression. His approaches bridge molecular biology, biochemistry, and animal models.

Specifically, he examines how genetic regulatory elements are organized spatially within the nucleus and how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. His work spans basic science to preclinical studies on blood diseases. His lab is developing genome and epigenome editing tools for the treatment of blood diseases.

Dr. Blobel is the co-director of the Epigenetics Institute at the University of Pennsylvania and co-director of the Spatial and Functional Genomics Program at CHOP.

Education and Training

MD, Ruprecht-Karls University, Germany, 1986

PhD, Rockefeller University (Molecular Oncology), 1991

Fellowship, Harvard Medical School (Hematology), 1997

Titles and Academic Titles

Investigator

Frank E. Weise III Endowed Chair in Pediatric Hematology

Professor of Pediatrics

Professional Memberships

American Society of Hematology

American Society for Microbiology

American Society for Biochemistry and Molecular Biology

American Society for Clinical Investigation

Member, Association of American Physicians

Professional Awards

Baldasare Award, 1997

Florence R.C. Murray Award, 1997

American Society of Hematology (ASH) Scholar Award, 1998

Cooley’s Anemia Foundation Junior Faculty Award, 1998

Foerderer Innovation Grant Award, 2008, 2013

Stanley N. Cohen Biomedical Research Award, 2014

The Children's Hospital of Philadelphia Mentor Award, 2015

Publication Highlights

Bartman CR, Hamagami N, Keller CA, Giardine B, Hardison RC, Blobel GA, Raj A. Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation. Mol Cell. 2019 Feb; 73(3):519-532.e4. PMID: 30554946
Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018 Jul; 361(6399):285-290. PMID: 30026227
Behera V, Evans P, Face CJ, Hamagami N, Sankaranarayanan L, Keller CA, Giardine B, Tan K, Hardison RC, Shi J, Blobel GA. Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility. Nat Commun. 2018 Feb; 9(1):782. PMID: 29472540
Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA. Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping. Mol Cell. 2016 Apr; 62(2):237-247. PMID: 27067601
Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014 Aug; 158(4):849-860. PMID: 25126789