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E-mail
blobel [at] chop.edu
Phone
Location - People View
Room 316H

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Gerd Blobel, MD, PhD
Gerd Blobel
Investigator

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

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Bio

Dr. Blobel is a Professor of Pediatrics and holds the Frank E. Weise III Chair in Hematology. He is co-director of the Epigenetics Institute at UPenn and co-director of the Spatial and Functional Genomics program at CHOP. Dr. Blobel has been continually funded by the NIH since arriving at Penn and holds an NIH MERIT award. In 2014 he won the Stanley N. Cohen Biomedical Research Award, and in 2015 received the Children's Hospital of Philadelphia Mentor Award. He was elected to the American Society of Clinical Investigation (2004) and Association of American Physicians (2008).

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

Education and Training

MD, Ruprecht-Karls University, Germany, 1986

PhD, Rockefeller University (Molecular Oncology), 1991

Fellowship, Harvard Medical School (Hematology), 1997

Titles and Academic Titles

Investigator

Frank E. Weise III Endowed Chair in Pediatric Hematology

Professor of Pediatrics

Professional Memberships

American Society of Hematology

American Society for Microbiology

American Society for Biochemistry and Molecular Biology

American Society for Clinical Investigation

Member, Association of American Physicians

Professional Awards

Baldasare Award, 1997

Florence R.C. Murray Award, 1997

American Society of Hematology (ASH) Scholar Award, 1998

Cooley’s Anemia Foundation Junior Faculty Award, 1998

Foerderer Innovation Grant Award, 2008, 2013

Stanley N. Cohen Biomedical Research Award, 2014

The Children's Hospital of Philadelphia Mentor Award, 2015

NIH MERIT Award

Publication Highlights

Zhang D, Huang P, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, and Blobel GA. Alteration of genome folding via engineered boundary insertion. Nature Genetics. 2020 Aug; In Press
Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison RC, Blobel GA. Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts. Blood. 2020 May; 135(22):1957-1968. doi: 10.1182/blood.2020005058
Zhang H, Emerson DJ, Gilgenast TG, Titus KR, Lan Y, Huang P, Zhang D, Wang H, Keller CA, Giardine B, Hardison RC, Phillips-Cremins JE, Blobel GA. Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature. 2019 Dec; 576(7785):158-162. doi: 10.1038/s41586-019-1778-y. Epub 2019 Nov 27
Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA. Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Cell Rep. 2019 Apr; 27(2):400-415.e5. doi: 10.1016/j.celrep.2019.03.057
Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018 Jul; 361(6399):285-290. doi: 10.1126/science.aao0932