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Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.
Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. One of the gene clusters he focuses on is the beta-globin locus and its associated diseases, such as sickle cell disease and thalassemia. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities.
In addition, Dr. Blobel is interested in the nuclear architecture, and genetic and epigenetic control of gene expression. His approaches bridge molecular biology, biochemistry, and animal models.
Specifically, he examines how genetic regulatory elements are organized spatially within the nucleus and how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. His work spans basic science to preclinical studies on blood diseases. His lab is developing genome and epigenome editing tools for the treatment of blood diseases.
Dr. Blobel is the co-director of the Epigenetics Institute at the University of Pennsylvania and co-director of the Spatial and Functional Genomics Program at CHOP.
Education and Training
MD, Ruprecht-Karls University, Germany, 1986
PhD, Rockefeller University (Molecular Oncology), 1991
Fellowship, Harvard Medical School (Hematology), 1997
Titles and Academic Titles
Frank E. Weise III Endowed Chair in Pediatric Hematology
Professor of Pediatrics
American Society of Hematology
American Society for Microbiology
American Society for Biochemistry and Molecular Biology
American Society for Clinical Investigation
Member, Association of American Physicians
Baldasare Award, 1997
Florence R.C. Murray Award, 1997
American Society of Hematology (ASH) Scholar Award, 1998
Cooley’s Anemia Foundation Junior Faculty Award, 1998
Foerderer Innovation Grant Award, 2008, 2013
Stanley N. Cohen Biomedical Research Award, 2014
The Children's Hospital of Philadelphia Mentor Award, 2015