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laskinb [at] email.chop.edu
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Room 2311

3501 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Benjamin L. Laskin, MD, MS
Benjamin L. Laskin
Attending Physician

Dr. Laskin's research focuses on the conduct of clinical investigations and translational studies designed to target mechanisms to prevent, treat, or slow the progression of chronic kidney disease in immunosuppressed patients, including children receiving a bone marrow or kidney transplant.

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Bio

Dr. Laskin is a pediatric nephrologist whose research focuses on how to prevent, treat, or slow the progression of kidney disease in children receiving a hematopoietic cell transplant (HCT).

He is the principal investigator on a career development award from the National Institutes of Diabetes and Digestive and Kidney Diseases designed to test the association between markers of immune imbalance, infection, and chronic kidney disease in children receiving an allogeneic HCT. To achieve this, Dr. Laskin and his colleagues developed a prospective observational cohort of 200 children receiving an allogeneic HCT who were followed until 2 years after transplant.

In addition, Dr. Laskin has conducted several clinical research projects on disease in immunosuppressed children resulting in publications on the study of infections after kidney transplant and HCT and the study of thrombotic microangiopathy after HCT.

Expanding on his research interests, Dr. Laskin also serves as the medical director for quality improvement for the Transplant Center at Children's Hospital of Philadelphia. In that role, he oversees several quality improvement projects, including improving vaccination rates and screening efforts for Epstein-Barr virus infection in children who have received a solid organ transplant.

Among his notable career achievements is a flourishing program with research on:

  • Hypertension, renal outcomes, and the role of complement in hematopoietic cell transplant-associated thrombotic microangiopathy
  • More frequent dialysis and survival for children with end-stage kidney disease
  • BK virus infections in children after hematopoietic cell transplantation

Education and Training

BS, Duke University (Economics), 2000

MD, University of Maryland School of Medicine, 2005

Fellowship, Cincinnati Children's Hospital Medical Center (Pediatric Nephrology), 2011

MS, University of Cincinnati (Clinical and Translational Research), 2011

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

American Society for Blood and Marrow Transplantation, 2011

American Society of Nephrology, 2011

American Society of Pediatric Nephrology, 2011

American Society of Transplantation, 2013

Professional Awards

Fellowship Scholarly Research Award, Cincinnati Children's Hospital Medical Center, 2011

American Society for Blood and Marrow Transplantation (ASBMT) New Investigator Award, 2013

Publication Highlights

Jodele S, Davies SM, Lane A, Khoury J, Dandoy C, Goebel J, Myers K, Grimley M, Bleesing J, El-Bietar J, Wallace G, Chima RS, Paff Z, Laskin BL. Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Blood. 2014 Jul; 124(4):645-53. PMID: 24876561
Jodele S, Licht C, Goebel J, Dixon BP, Zhang K, Sivakumaran TA, Davies SM, Pluthero FG, Lu L, Laskin BL. Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Blood. 2013 Sep; 122(12):2003-7. PMID: 23814021
Mitsnefes MM, Laskin BL, Dahhou M, Zhang X, Foster BJ. Mortality risk among children initially treated with dialysis for end-stage kidney disease, 1990-2010. JAMA. 2013 May; 309(18):1921-9. PMID: 23645144
Laskin BL, Goebel J, Davies SM, Jodele S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood. 2011 Aug; 118(6):1452-62. PMID: 21596850
Botteman MF, Pashos CL, Redaelli A, Laskin B, Hauser R. The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics. 2003 Jan; 21(18):1315-30. PMID: 14750899