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About the Henrickson Laboratory
The impact on T cell immunometabolic function in chronic inflammation is a key focus of the Henrickson Lab. The lab studies the impact of pediatric asthma and obesity on immune function, including the response to vaccines. The hypotheses from initial human studies are being evaluated in animal models of obese asthma and in human cells in vitro and extended in new human studies.
The Henrickson Lab also investigates mechanisms of T cell dysfunction in primary immunodeficiency. Researchers in the lab have studied the earliest stages of T cell activation and used whole-exome sequencing to uncover novel causes of immunodeficiency in families with severe persistent skin viral infections with genetic disease. The lab is now starting to study T cell immunometabolic dysfunction in primary immunodeficiency.
The lab team employs complementary approaches across research models to conduct studies, leveraging detailed immunophenotyping and metabolic characterization of immune dysfunction in patients to identify mechanistic hypotheses to evaluate in animal models and human cells in vitro.
The Henrickson Lab appreciates our supporters for their contributions to our work.
AAAAI Foundation: Funding research that leads to the prevention and cure of asthma and allergic and immunologic disease.
Chan Zuckerberg Initiative: Building a Better Future for Everyone.
National Institute of Allergy and Infectious Diseases
Primary Immune Deficiency Treatment Consortium: Rare Disease Clinical Research Network
Burroughs Wellcome Fund: Improving human health through education and powering discovery in frontiers of greatest need.