Division of Pulmonary Medicine

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Many of the common respiratory diseases seen in adults have their origins in childhood. The robust research programs in the Division of Pulmonary Medicine reflect the potential child-adult continuum and the trajectory of respiratory diseases and conditions. These programs highlight investigators’ diverse clinical interests across the spectrum of lung and chest wall diseases, and sleep disorders.

There are several centers within the Division that support a broad array of research endeavors and advance pediatric research and healthcare. The Cystic Fibrosis Center houses a basic science program, targeting protein trafficking and pharmacologic correction of the basic defect in the cystic fibrosis transmembrane regulatory protein.

The Sleep Center performs basic physiologic studies of airway neural control, and cerebral blood flow and oxygenation responses to hypercarbia; normal infant sleep parameters and the effects of micrognathia; efficacy and effectiveness of behavioral interventions and cross-cultural considerations of sleep in infants and toddlers; primary care-based sleep and behavioral interventions for socio-economically disadvantaged children; multi-center studies of the effects of adenotonsillectomy on the neurodevelopmental outcomes of obstructive sleep apnea.

In addition, the Asthma Center performs quality improvement projects aimed at best asthma practices, while the Technology Dependence Center performs physiologic research on the trajectory of airway growth and physiology in infants born with congenital space occupying lesions of the chest, such as congenital diaphragmatic hernia, omphalocele, and congenital pulmonary malformations.

The Division also features the Thoracic Insufficiency Center, the Transplant, Primary Ciliary Dyskinesia Center, the Interstitial Lung Disease Center, and the Aerodigestive Center. These centers perform innovative studies aimed at areas like the effects of neuromuscular disorders and skeletal chest wall abnormalities on lung function and growth, lung function outcomes of childhood cancer, advanced bronchoscopic techniques, biobanking in the lung transplant population, and novel techniques of assessing lung function in children too young to perform spirometry.

All studies in the Division of Pulmonary Medicine have a common theme of assessing normal and pathologic growth and development of the lungs and chest wall. Thus, in a real sense, the research conducted by Division investigators is aimed not only at children, but at the adults they will become.