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Research in the Brodeur Lab currently focuses on nanoparticle (NP) drug delivery. Working closely with Michael Chorny, PhD, and Ivan Alferiev, PhD, at Children's Hospital of Philadelphia, the lab aims to develop more effective and less toxic therapies for pediatric cancers, especially solid tumors like neuroblastoma. Although agents targeting specific genes, proteins, and pathways are needed, targeted drug delivery could dramatically improve efficacy and decrease toxicity.
The Brodeur Lab is developing several novel approaches for nanoparticle design and formulation. Furthermore, they are using several robust animal models of neuroblastoma (flank, orthotopic, and PDX xenografts; transgenic TH-MYCN mice), as well as sarcomas (RMS, EWS, OS) for testing nanocarrier formulations. This work has led to three recent publications demonstrating the lab's successful collaboration to study nanocarrier delivery of a PLA-PEG NP carrying SN38 co-drug with tocopherol succinate or oxyacetate.
Currently, the lab is working to optimize nanocarrier drug delivery by development of single-component, multivalent nanomedicines containing camptothecin derivatives for enhanced delivery of cancer therapeutics to pediatric solid tumors like neuroblastoma and sarcomas.
Director, Cancer Predisposition Program
Dr. Broedur’s research interests focus on nanoparticle drug delivery and cancer predisposition. He is also interested in identifying novel cancer predisposition genes, and developing enhanced surveillance techniques to identify cancer early in predisposed individuals with the hope of improving outcome and reducing side effects.