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Abemaciclib For Solid Tumors
This study is now recruiting.
The purpose of this study is to determine the highest safe dose of abemaciclib in patients with relapsed or treatment refractory solid tumors given in combination with the chemotherapy drugs, irinotecan and temozolomide (Part A) or in combination with just temozolomide (Part B).
Who Do I Contact?
If you are interested in participating in the study or want to learn more please contact our study team at RODRIGUECS [at] chop.edu or 267-426-9293.
Eligibility & Criteria
This study will enroll male and female patients 18 years and younger with any relapsed or treatment refractory solid tumor that have progressed on standard treatments. Subjects will receive abemaciclib (study drug) in combination with the chemotherapy drugs, irinotecan and temozolomide or just temozolomide. Subjects will be asked to keep a drug diary and write down information about side effects and when they took the study drug. Study visits will also include the following assessments: blood tests, electrocardiograms (ECGs), and completion of palatability questionnaire.