Genome-wide Association Studies | CHOP Research Institute

Dr. Crane works on the development and oversight of early phase clinical trials for pediatric cancers.

E-mail:

cranej2 [at] chop.edu

Goldmuntz Laboratory

The Goldmuntz Laboratory manages a cardiac biorepository of case and parental samples, all of which have congenital heart disease.

Researchers in the Felix Laboratory study the molecular mechanisms underlying the formation of chromosomal translocations of the mixed-lineage leukemia (MLL) gene and the effects of MLL translocations on the development of high-risk forms of leukemia that occur in infants and as a chemotherapy complication.

Cornerstone Blog

Could Genomic Biomarkers Help Reduce Incidence of Heart Disease?

Published on

Nov 19, 2019

Using eMERGE Network data, researchers identified genome-wide significant loci that might be biomarkers for risk of cardiovascular disease.

Christopher J. Cardinale, MD, PhD

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:

cardinalec [at] chop.edu

Carolyn A. Felix, MD

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:

felix [at] chop.edu

Cornerstone Blog

Gene Study Points to Novel Pathway for Diabetes Treatment

Published on

Jun 23, 2014

New research from The Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania details how a diabetes-related gene functions on a biological pathway that affects the release of insulin.

Cornerstone Blog

Autism Gene Networks Could Offer Treatment Targets

Published on

Jun 11, 2014

After analyzing the DNA from thousands of patients, investigators from Children’s Hospital have uncovered several gene networks that may play important roles in autism.