Pharmacokinetics | CHOP Research Institute

NIH-funded Study Examines Interplay Between Immune Response and Antibiotic Dosage

Published on

Nov 20, 2023

Researchers Study Effects of Antibiotic Dosage on Immune Response

The NIH-funded study, PRESCRIBE, will help researchers understand how antibiotics affect organ function recovery and respiratory microbiota in children with sepsis.

Clinical Pharmacology Research Affinity Group

The mission of the Clinical Pharmacology RAG is to support CHOP investigators engaged in clinical pharmacology research, foster collaborations within the CHOP/Penn research community, and create additional educational opportunities for trainees.

OT-58 for Homocystinuria

This research study is focused on patients who have Cystathionine beta synthase deficiency Homocystinuria (CBSDH).

Cancer Pharmacology Laboratory

The Cancer Pharmacology Laboratory supports clinical trials of new mechanistically targeted and immune-based anticancer drugs by conducting pre-clinical and clinical pharmacology studies of the agents. The lab also studies conventional anticancer drugs to develop more rational and effective dosing methods, and the lab team is developing ci

Kevin Downes, MD

The research interests of Dr. Downes focus on antimicrobial clinical pharmacology and pharmacoepidemiology in children with a goal to identify novel approaches to optimize efficacy, minimize toxicity, and limit antimicrobial resistance from antibiotics.

E-mail:

downeskj [at] chop.edu